Dental staining after doxycycline use in children

Show simple item record Poyhonen, Heidi Nurmi, Mirka Peltola, Ville Alaluusua, Satu Ruuskanen, Olli Lahdesmaki, Tuire 2017-10-12T13:13:00Z 2017-10-12T13:13:00Z 2017-10
dc.identifier.citation Poyhonen , H , Nurmi , M , Peltola , V , Alaluusua , S , Ruuskanen , O & Lahdesmaki , T 2017 , ' Dental staining after doxycycline use in children ' , Journal of Antimicrobial Chemotherapy , vol. 72 , no. 10 , pp. 2887-2890 .
dc.identifier.other PURE: 90936063
dc.identifier.other PURE UUID: 40481d3c-48e2-44aa-a90b-b8d9c40592c9
dc.identifier.other WOS: 000411516200031
dc.identifier.other Scopus: 85030694109
dc.description.abstract Background: The use of doxycycline has been avoided before 8 years of age due to known dental staining caused by tetracyclines, although doxycycline differs from classical tetracyclines in many ways. Doxycycline is still an important antimicrobial agent, but its dental safety is not well studied. Objectives: To examine the state of permanent teeth after doxycycline exposure in children,8 years of age. Methods: Details of doxycycline treatment were collected from medical records. After the eruption of permanent teeth the dental status was examined by an experienced paediatric dentist for detection of dental staining and enamel hypoplasia. The resulting dental photographs were evaluated by a second independent experienced paediatric dentist. Results: The mean age of 38 study subjects at the time of doxycycline treatment was 4.7 years (range 0.6-7.9 years, SD 2.3). The doxycycline dose was 10 mg/kg/day (varying from 8 to 10 mg/kg/day) for the first 2-3 days and 5mg/kg/day (varying from 2.5 to 10mg/kg/day) thereafter. The mean length of the treatment was 12.5days (SD 6.0) and ranged from 2 to 28 days. Tetracycline-like staining or enamel hypoplasia of developing teeth was detected in none of the subjects. Conclusions: Doxycycline treatment of small children does not seem to induce permanent tooth staining. en
dc.format.extent 4
dc.language.iso eng
dc.relation.ispartof Journal of Antimicrobial Chemotherapy
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject TEETH
dc.subject 317 Pharmacy
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Dental staining after doxycycline use in children en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization University of Helsinki
dc.contributor.organization Department of Oral and Maxillofacial Diseases
dc.contributor.organization HUS Head and Neck Center
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0305-7453
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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