Lymphangiogenesis guidance by paracrine and pericellular factors

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http://hdl.handle.net/10138/225798

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Vaahtomeri , K , Karaman , S , Makinen , T & Alitalo , K 2017 , ' Lymphangiogenesis guidance by paracrine and pericellular factors ' , Genes & Development , vol. 31 , no. 16 , pp. 1615-1634 . https://doi.org/10.1101/gad.303776.117

Title: Lymphangiogenesis guidance by paracrine and pericellular factors
Author: Vaahtomeri, Kari; Karaman, Sinem; Makinen, Taija; Alitalo, Kari
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Translational Cancer Biology (TCB) Research Programme
University of Helsinki, University of Helsinki
Date: 2017-08-15
Language: eng
Number of pages: 20
Belongs to series: Genes & Development
ISSN: 0890-9369
URI: http://hdl.handle.net/10138/225798
Abstract: Lymphatic vessels are important for tissue fluid homeostasis, lipid absorption, and immune cell trafficking and are involved in the pathogenesis of several human diseases. The mechanisms by which the lymphatic vasculature network is formed, remodeled, and adapted to physiological and pathological challenges are controlled by an intricate balance of growth factor and biomechanical cues. These transduce signals for the readjustment of gene expression and lymphatic endothelial migration, proliferation, and differentiation. In this review, we describe several of these cues and how they are integrated for the generation of functional lymphatic vessel networks.
Subject: lymphangiogenesis
VEGF-C
VEGFR3
lymphatic vessel sprouting
interstitial fluid pressure
lymphedema
lymphatic vessel basement membrane
ENDOTHELIAL-GROWTH-FACTOR
LYMPHATIC VESSEL FORMATION
MORPHOGENESIS IN-VITRO
TIP CELL-FORMATION
C VEGF-C
TUMOR LYMPHANGIOGENESIS
FACTOR RECEPTOR-3
VASCULAR DEVELOPMENT
NODE METASTASIS
EXTRACELLULAR-MATRIX
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
1184 Genetics, developmental biology, physiology
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