Nanosilver-Silica Composite : Prolonged Antibacterial Effects and Bacterial Interaction Mechanisms for Wound Dressings

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http://hdl.handle.net/10138/225854

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Mosselhy , D A , Granbohm , H , Hynonen , U , Ge , Y , Palva , A , Nordstrom , K & Hannula , S-P 2017 , ' Nanosilver-Silica Composite : Prolonged Antibacterial Effects and Bacterial Interaction Mechanisms for Wound Dressings ' , Nanomaterials , vol. 7 , no. 9 , 261 . https://doi.org/10.3390/nano7090261 , https://doi.org/10.3390/nano7090261

Title: Nanosilver-Silica Composite : Prolonged Antibacterial Effects and Bacterial Interaction Mechanisms for Wound Dressings
Author: Mosselhy, Dina A.; Granbohm, Henrika; Hynonen, Ulla; Ge, Yanling; Palva, Airi; Nordstrom, Katrina; Hannula, Simo-Pekka
Other contributor: University of Helsinki, Aalto University
University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki

Date: 2017-09
Language: eng
Number of pages: 19
Belongs to series: Nanomaterials
ISSN: 2079-4991
DOI: https://doi.org/10.3390/nano7090261
URI: http://hdl.handle.net/10138/225854
Abstract: Infected superficial wounds were traditionally controlled by topical antibiotics until the emergence of antibiotic-resistant bacteria. Silver (Ag) is a kernel for alternative antibacterial agents to fight this resistance quandary. The present study demonstrates a method for immobilizing small-sized (similar to 5 nm) silver nanoparticles on silica matrix to form a nanosilver-silica (Ag-SiO2) composite and shows the prolonged antibacterial effects of the composite in vitro. The composite exhibited a rapid initial Ag release after 24 h and a slower leaching after 48 and 72 h and was effective against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli). Ultraviolet (UV)-irradiation was superior to filter-sterilization in retaining the antibacterial effects of the composite, through the higher remaining Ag concentration. A gauze, impregnated with the Ag-SiO2 composite, showed higher antibacterial effects against MRSA and E. coli than a commercial Ag-containing dressing, indicating a potential for the management and infection control of superficial wounds. Transmission and scanning transmission electron microscope analyses of the composite-treated MRSA revealed an interaction of the released silver ions with the bacterial cytoplasmic constituents, causing ultimately the loss of bacterial membranes. The present results indicate that the Ag-SiO2 composite, with prolonged antibacterial effects, is a promising candidate for wound dressing applications.
Subject: silver nanoparticles
silica
composite
prolonged silver leaching
antibacterial effects
mechanisms of action
wound dressings
RESISTANT STAPHYLOCOCCUS-AUREUS
GRAM-NEGATIVE BACTERIA
SILVER NANOPARTICLES
ESCHERICHIA-COLI
INFECTION-CONTROL
TOPICAL SILVER
IN-VITRO
MANAGEMENT
EFFICACY
BURN
221 Nano-technology
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