Efficacy of progressive aquatic resistance training for tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis : a randomised controlled trial

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Munukka , M , Waller , B , Rantalainen , T , Hakkinen , A , Nieminen , M T , Lammentausta , E , Kujala , U M , Paloneva , J , Sipila , S , Peuna , A , Kautiainen , H , Selanne , H , Kiviranta , I & Heinonen , A 2016 , ' Efficacy of progressive aquatic resistance training for tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis : a randomised controlled trial ' , Osteoarthritis and Cartilage , vol. 24 , no. 10 , pp. 1708-1717 . https://doi.org/10.1016/j.joca.2016.05.007

Title: Efficacy of progressive aquatic resistance training for tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis : a randomised controlled trial
Author: Munukka, M.; Waller, B.; Rantalainen, T.; Hakkinen, A.; Nieminen, M. T.; Lammentausta, E.; Kujala, U. M.; Paloneva, J.; Sipila, S.; Peuna, A.; Kautiainen, H.; Selanne, H.; Kiviranta, I.; Heinonen, A.
Other contributor: University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Clinicum



Date: 2016-10
Language: eng
Number of pages: 10
Belongs to series: Osteoarthritis and Cartilage
ISSN: 1063-4584
DOI: https://doi.org/10.1016/j.joca.2016.05.007
URI: http://hdl.handle.net/10138/225972
Abstract: Objective: To study the efficacy of aquatic resistance training on biochemical composition of tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis (OA). Design: Eighty seven volunteer postmenopausal women, aged 60-68 years, with mild knee OA (Kellgren-Lawrence grades I/II and knee pain) were recruited and randomly assigned to an intervention (n = 43) and control (n = 44) group. The intervention group participated in 48 supervised aquatic resistance training sessions over 16 weeks while the control group maintained usual level of physical activity. The biochemical composition of the medial and lateral tibiofemoral cartilage was estimated using single-slice transverse relaxation time (T2) mapping and delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC index). Secondary outcomes were cardiorespiratory fitness, isometric knee extension and flexion force and knee injury and OA outcome (KOOS) questionnaire. Results: After 4-months aquatic training, there was a significant decrease in both T2 -1.2 ms (95% confidence interval (CI): -2.3 to -0.1, P = 0.021) and dGEMRIC index -23 ms (-43 to -3, P = 0.016) in the training group compared to controls in the full thickness posterior region of interest (ROI) of the medial femoral cartilage. Cardiorespiratory fitness significantly improved in the intervention group by 9.8% (P = 0.010). Conclusions: Our results suggest that, in postmenopausal women with mild knee OA, the integrity of the collagen-interstitial water environment (T2) of the tibiofemoral cartilage may be responsive to low shear and compressive forces during aquatic resistance training. More research is required to understand the exact nature of acute responses in dGEMRIC index to this type of loading. Further, aquatic resistance training improves cardiorespiratory fitness. (C) 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Subject: Osteoarthritis
Aquatic exercise
Magnetic resonance imaging (MRI)
Cartilage
Randomised controlled trial
GADOLINIUM-ENHANCED MRI
ARTICULAR-CARTILAGE
GLYCOSAMINOGLYCAN DISTRIBUTION
PATELLAR CARTILAGE
PHYSICAL-ACTIVITY
QUANTITATIVE MRI
RUNNING EXERCISE
JOINT
THICKNESS
BONE
3126 Surgery, anesthesiology, intensive care, radiology
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