Health-related quality of life of primary care patients with depressive disorders

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http://hdl.handle.net/10138/228038

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Riihimaki , K , Sintonen , H , Vuorilehto , M , Jylhä , P , Saarni , S & Isometsa , E 2016 , ' Health-related quality of life of primary care patients with depressive disorders ' , European Psychiatry , vol. 37 , pp. 28-34 . https://doi.org/10.1016/j.eurpsy.2016.04.008

Title: Health-related quality of life of primary care patients with depressive disorders
Author: Riihimaki, K.; Sintonen, H.; Vuorilehto, M.; Jylhä, P.; Saarni, S.; Isometsa, E.
Contributor: University of Helsinki, Harri Sintonen Research Group
University of Helsinki, Clinicum
University of Helsinki, Department of Psychiatry
University of Helsinki, Clinicum
Date: 2016-09
Language: eng
Number of pages: 7
Belongs to series: European Psychiatry
ISSN: 0924-9338
URI: http://hdl.handle.net/10138/228038
Abstract: Background: Depressive disorders are known to impair health-related quality of life (HRQoL) both in the short and long term. However, the determinants of long-term HRQoL outcomes in primary care patients with depressive disorders remain unclear. Methods: In a primary care cohort study of patients with depressive disorders, 82% of 137 patients were prospectively followed up for five years. Psychiatric disorders were diagnosed with SCID-I/P and SCID-II interviews; clinical, psychosocial and socio-economic factors were investigated by rating scales and questionnaires plus medical and psychiatric records. HRQoL was measured with the generic 15D instrument at baseline and five years, and compared with an age-standardized general population sample (n = 3707) at five years. Results: Depression affected the 15D total score and almost all dimensions at both time points. At the end of follow-up, HRQoL of patients in major depressive episode (MDE) was particularly low, and the association between severity of depression (Beck Depression Inventory [BDI]) and HRQoL was very strong (r = -0.804). The most significant predictors for change in HRQoL were changes in BDI and Beck Anxiety Inventory (BAI) scores. The mean 15D score of depressive primary care patients at five years was much worse than in the age-standardized general population, reaching normal range only among patients who were in clinical remission and had virtually no symptoms. Conclusions: Among depressive primary care patients, presence of current depressive symptoms markedly reduces HRQoL, with symptoms of concurrent anxiety also having a marked impact. For HRQoL to normalize, current depressive and anxiety symptoms must be virtually absent. (C) 2016 Elsevier Masson SAS. All rights reserved.
Subject: Depression
Health-related quality of life
Comorbidity
Follow-up
Primary care
GENERAL-POPULATION SURVEY
UTILITY INSTRUMENTS
DSM-IV
DISEASE
SCALE
15D
COMORBIDITY
INVENTORY
REMISSION
ANXIETY
3124 Neurology and psychiatry
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