Health-related quality of life of primary care patients with depressive disorders

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dc.contributor.author Riihimaki, K.
dc.contributor.author Sintonen, H.
dc.contributor.author Vuorilehto, M.
dc.contributor.author Jylhä, P.
dc.contributor.author Saarni, S.
dc.contributor.author Isometsa, E.
dc.date.accessioned 2017-10-26T21:07:31Z
dc.date.available 2021-12-17T18:47:21Z
dc.date.issued 2016-09
dc.identifier.citation Riihimaki , K , Sintonen , H , Vuorilehto , M , Jylhä , P , Saarni , S & Isometsa , E 2016 , ' Health-related quality of life of primary care patients with depressive disorders ' , European Psychiatry , vol. 37 , pp. 28-34 . https://doi.org/10.1016/j.eurpsy.2016.04.008
dc.identifier.other PURE: 70328246
dc.identifier.other PURE UUID: 17c424ea-df49-4153-a61b-45fad3d04848
dc.identifier.other WOS: 000384021500005
dc.identifier.other Scopus: 84989874356
dc.identifier.uri http://hdl.handle.net/10138/228038
dc.description.abstract Background: Depressive disorders are known to impair health-related quality of life (HRQoL) both in the short and long term. However, the determinants of long-term HRQoL outcomes in primary care patients with depressive disorders remain unclear. Methods: In a primary care cohort study of patients with depressive disorders, 82% of 137 patients were prospectively followed up for five years. Psychiatric disorders were diagnosed with SCID-I/P and SCID-II interviews; clinical, psychosocial and socio-economic factors were investigated by rating scales and questionnaires plus medical and psychiatric records. HRQoL was measured with the generic 15D instrument at baseline and five years, and compared with an age-standardized general population sample (n = 3707) at five years. Results: Depression affected the 15D total score and almost all dimensions at both time points. At the end of follow-up, HRQoL of patients in major depressive episode (MDE) was particularly low, and the association between severity of depression (Beck Depression Inventory [BDI]) and HRQoL was very strong (r = -0.804). The most significant predictors for change in HRQoL were changes in BDI and Beck Anxiety Inventory (BAI) scores. The mean 15D score of depressive primary care patients at five years was much worse than in the age-standardized general population, reaching normal range only among patients who were in clinical remission and had virtually no symptoms. Conclusions: Among depressive primary care patients, presence of current depressive symptoms markedly reduces HRQoL, with symptoms of concurrent anxiety also having a marked impact. For HRQoL to normalize, current depressive and anxiety symptoms must be virtually absent. (C) 2016 Elsevier Masson SAS. All rights reserved. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof European Psychiatry
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Depression
dc.subject Health-related quality of life
dc.subject Comorbidity
dc.subject Follow-up
dc.subject Primary care
dc.subject GENERAL-POPULATION SURVEY
dc.subject UTILITY INSTRUMENTS
dc.subject DSM-IV
dc.subject DISEASE
dc.subject SCALE
dc.subject 15D
dc.subject COMORBIDITY
dc.subject INVENTORY
dc.subject REMISSION
dc.subject ANXIETY
dc.subject 3124 Neurology and psychiatry
dc.title Health-related quality of life of primary care patients with depressive disorders en
dc.type Article
dc.contributor.organization Harri Sintonen Research Group
dc.contributor.organization Department of Public Health
dc.contributor.organization Clinicum
dc.contributor.organization Department of Psychiatry
dc.contributor.organization HUS Psychiatry
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.eurpsy.2016.04.008
dc.relation.issn 0924-9338
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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