Conclusions about intervention effects should not be based on surrogate end points : [Letter]

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Hemilä , H 2007 , ' Conclusions about intervention effects should not be based on surrogate end points : [Letter] ' , Free Radical Biology & Medicine , vol. 42 , no. 4 , pp. 578-578 . https://doi.org/10.1016/j.freeradbiomed.2006.11.035

Title: Conclusions about intervention effects should not be based on surrogate end points : [Letter]
Author: Hemilä, Harri
Contributor organization: Department of Public Health
Date: 2007
Language: eng
Number of pages: 1
Belongs to series: Free Radical Biology & Medicine
ISSN: 0891-5849
DOI: https://doi.org/10.1016/j.freeradbiomed.2006.11.035
URI: http://hdl.handle.net/10138/228089
Abstract: Experts of controlled clinical trials argue that decisions on medical interventions should be based on clinically relevant outcomes and not on surrogates such as laboratory measurements. There are quite a few examples in which the effect on a surrogate end point substantially diverged from the effect on a clinically relevant outcome. In this respect, the recent paper by Bruno et al. is problematic as it proposed higher vitamin E intakes for smokers on the basis of greater disappearance rate of alpha-tocopherol in the plasma of smokers. The disappearance rate is a surrogate end point with no validated relation to any clinically relevant outcome.
Subject: VITAMIN-E
SUPPLEMENTATION
SMOKERS
TRIALS
314 Health sciences
3142 Public health care science, environmental and occupational health
Peer reviewed: No
Usage restriction: openAccess
Self-archived version: acceptedVersion


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