Small trials focusing on surrogate end points may be uninformative : [Letter]

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Hemilä , H 2007 , ' Small trials focusing on surrogate end points may be uninformative : [Letter] ' , European Journal of Applied Physiology , vol. 99 , no. 6 , pp. 707-708 . https://doi.org/10.1007/s00421-006-0387-2

Title: Small trials focusing on surrogate end points may be uninformative : [Letter]
Author: Hemilä, Harri
Contributor organization: Department of Public Health
Clinicum
Date: 2007
Language: eng
Number of pages: 2
Belongs to series: European Journal of Applied Physiology
ISSN: 1439-6319
DOI: https://doi.org/10.1007/s00421-006-0387-2
URI: http://hdl.handle.net/10138/228092
Abstract: Experts of controlled clinical trials argue that conclusions about the effects of medical interventions should be based on clinically relevant outcomes and not on the surrogates such as laboratory measurements. There are several examples in which the effect on a clinically relevant outcome considerably diverged from the effect on a surrogate end point. In this respect, the recent paper by Davison and Gleeson (2006) is somewhat problematic.
Subject: VITAMIN-C SUPPLEMENTATION
314 Health sciences
Peer reviewed: No
Usage restriction: openAccess
Self-archived version: acceptedVersion


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