Assessment of blinding may be inappropriate after the trial : [Letter]

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http://hdl.handle.net/10138/228099

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Hemilä , H 2005 , ' Assessment of blinding may be inappropriate after the trial : [Letter] ' , Contemporary Clinical Trials , vol. 26 , no. 4 , pp. 512-514 . https://doi.org/10.1016/j.cct.2005.04.002

Titel: Assessment of blinding may be inappropriate after the trial : [Letter]
Författare: Hemilä, Harri
Upphovmannens organisation: Department of Public Health
Datum: 2005
Språk: eng
Sidantal: 3
Tillhör serie: Contemporary Clinical Trials
ISSN: 1551-7144
DOI: https://doi.org/10.1016/j.cct.2005.04.002
Permanenta länken (URI): http://hdl.handle.net/10138/228099
Abstrakt: In their paper discussing the assessment of blinding in clinical trials, Bang et al. based their analysis on the premise that "all participants randomly guess their assignment... This is the most ideal scenario in reality". However, this premise makes an implicit assumption that the drug does not differ from placebo in any physiological effects that a person could observe subjectively, which is a very strong assumption. If a drug is truly effective, such as penicillin for pneumococcal pneumonia, both the patient and the physician can infer the treatment with high certainty by subjective observations. Thus, when the drug is truly effective, we are expecting "breaking of blindness".
Subject: VITAMIN-C
COMMON COLD
ASCORBIC-ACID
DISSENT
314 Health sciences
Referentgranskad: Nej
Användningsbegränsning: openAccess
Parallelpublicerad version: acceptedVersion


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