Assessment of blinding may be inappropriate after the trial : [Letter]

Show simple item record Hemilä, Harri 2017-10-29T17:31:00Z 2017-10-29T17:31:00Z 2005
dc.identifier.citation Hemilä , H 2005 , ' Assessment of blinding may be inappropriate after the trial : [Letter] ' , Contemporary Clinical Trials , vol. 26 , no. 4 , pp. 512-514 .
dc.identifier.other PURE: 7434708
dc.identifier.other PURE UUID: 4c4f7647-1559-4e2e-b8e3-d260bf29930d
dc.identifier.other WOS: 000231398300012
dc.identifier.other Scopus: 33644697973
dc.identifier.other ORCID: /0000-0002-4710-307X/work/50015578
dc.description.abstract In their paper discussing the assessment of blinding in clinical trials, Bang et al. based their analysis on the premise that "all participants randomly guess their assignment... This is the most ideal scenario in reality". However, this premise makes an implicit assumption that the drug does not differ from placebo in any physiological effects that a person could observe subjectively, which is a very strong assumption. If a drug is truly effective, such as penicillin for pneumococcal pneumonia, both the patient and the physician can infer the treatment with high certainty by subjective observations. Thus, when the drug is truly effective, we are expecting "breaking of blindness". en
dc.format.extent 3
dc.language.iso eng
dc.relation.ispartof Contemporary Clinical Trials
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject VITAMIN-C
dc.subject COMMON COLD
dc.subject ASCORBIC-ACID
dc.subject DISSENT
dc.subject 314 Health sciences
dc.title Assessment of blinding may be inappropriate after the trial : [Letter] en
dc.type Article
dc.contributor.organization Department of Public Health
dc.description.reviewstatus Non peer reviewed
dc.relation.issn 1551-7144
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion
dc.type.version publishedVersion

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