Functional maturation in preterm infants measured by serial recording of cortical activity

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http://hdl.handle.net/10138/228262

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Stevenson , N J , Oberdorfer , L , Koolen , N , O'Toole , J M , Werther , T , Klebermass-Schrehof , K & Vanhatalo , S 2017 , ' Functional maturation in preterm infants measured by serial recording of cortical activity ' , Scientific Reports , vol. 7 , 12969 . https://doi.org/10.1038/s41598-017-13537-3

Title: Functional maturation in preterm infants measured by serial recording of cortical activity
Author: Stevenson, N. J.; Oberdorfer, L.; Koolen, N.; O'Toole, J. M.; Werther, T.; Klebermass-Schrehof, K.; Vanhatalo, S.
Contributor organization: HUS Medical Imaging Center
Department of Neurosciences
Faculty of Medicine
University of Helsinki
Kliinisen neurofysiologian yksikkö
Clinicum
Neurologian yksikkö
Department of Diagnostics and Therapeutics
Date: 2017-10-11
Language: eng
Number of pages: 7
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-017-13537-3
URI: http://hdl.handle.net/10138/228262
Abstract: Minimally invasive, automated cot-side tools for monitoring early neurological development can be used to guide individual treatment and benchmark novel interventional studies. We develop an automated estimate of the EEG maturational age (EMA) for application to serial recordings in preterm infants. The EMA estimate was based on a combination of 23 computational features estimated from both the full EEG recording and a period of low EEG activity (46 features in total). The combination function (support vector regression) was trained using 101 serial EEG recordings from 39 preterm infants with a gestational age less than 28 weeks and normal neurodevelopmental outcome at 12 months of age. EEG recordings were performed from 24 to 38 weeks post-menstrual age (PMA). The correlation between the EMA and the clinically determined PMA at the time of EEG recording was 0.936 (95% CI: 0.932-0.976; n = 39). All infants had an increase in EMA between the first and last EEG recording and 57/62 (92%) of repeated measures within an infant had an increasing EMA with PMA of EEG recording. The EMA is a surrogate measure of age that can accurately determine brain maturation in preterm infants.
Subject: NEONATAL INTENSIVE-CARE
GESTATIONAL-AGE
PREMATURE-INFANTS
BRAIN DYSMATURITY
EEG ACTIVITY
BIRTH
AMPLITUDE
SLEEP
ELECTROENCEPHALOGRAM
ENCEPHALOPATHY
3124 Neurology and psychiatry
3112 Neurosciences
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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