Speckle tracking echocardiography detects decreased cardiac longitudinal function in anthracycline-exposed survivors of childhood cancer

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http://hdl.handle.net/10138/228391

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Ylanen , K , Eerola , A , Vettenranta , K & Poutanen , T 2016 , ' Speckle tracking echocardiography detects decreased cardiac longitudinal function in anthracycline-exposed survivors of childhood cancer ' , European journal of pediatrics , vol. 175 , no. 10 , pp. 1379-1386 . https://doi.org/10.1007/s00431-016-2776-9

Title: Speckle tracking echocardiography detects decreased cardiac longitudinal function in anthracycline-exposed survivors of childhood cancer
Author: Ylanen, Kaisa; Eerola, Anneli; Vettenranta, Kim; Poutanen, Tuija
Contributor: University of Helsinki, Clinicum
Date: 2016-10
Language: eng
Number of pages: 8
Belongs to series: European journal of pediatrics
ISSN: 0340-6199
URI: http://hdl.handle.net/10138/228391
Abstract: Longitudinal motion significantly contributes to the contraction of the ventricles. We studied the left (LV) and right ventricular (RV) longitudinal functions in 75 anthracycline-exposed, long-term childhood cancer survivors and 75 healthy controls with conventional echocardiography, tissue Doppler imaging (TDI), speckle tracking echocardiography (STE) of the mitral and tricuspid annular motion, and real-time three-dimensional echocardiography (RT-3DE). Cardiac magnetic resonance (CMR) imaging was performed on 61 of the survivors. The survivors had lower systolic myocardial velocities in the LV and lower diastolic velocities in both ventricles by TDI than did their healthy peers. The STE-based tissue motion annular displacement (TMAD) values describing the LV and RV systolic longitudinal function (MAD and TAD mid%, respectively) were also lower among the survivors (15.4 +/- 2.4 vs. 16.1 +/- 2.2 %, p = 0.049 and 22.5 +/- 3.0 vs. 23.5 +/- 3.0 %, p = 0.035). MAD and TAD mid in millimeters correlated with the respective ventricular volumes measured with RT-3DE or CMR. Conclusion: Childhood cancer survivors exposed to low to moderate anthracycline doses had decreased longitudinal systolic and diastolic functions (TDI or STE) compared with healthy controls. The STE-based TMAD is a fast and reproducible method to assess cardiac longitudinal function.
Subject: Anthracycline
Child
Malignancy
Speckle tracking
Tissue Doppler imaging
RIGHT-VENTRICULAR FUNCTION
TISSUE DOPPLER-ECHOCARDIOGRAPHY
MITRAL ANNULAR DISPLACEMENT
LONG-TERM SURVIVORS
MYOCARDIAL DYSFUNCTION
MAGNETIC-RESONANCE
3-DIMENSIONAL ECHOCARDIOGRAPHY
HEART-FAILURE
CHILDREN
THERAPY
3123 Gynaecology and paediatrics
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