Clinical findings of extranodal SNT lymphoid malignancies in a four-decade single-centre series

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dc.contributor.author Vähämurto, Pauli
dc.contributor.author Silventoinen, Kaija
dc.contributor.author Vento, Seija
dc.contributor.author Karjalainen-Lindsberg, Marja-Liisa
dc.contributor.author Haapaniemi, Aaro
dc.contributor.author Back, Leif
dc.contributor.author Mannisto, Susanna
dc.contributor.author Leppa, Sirpa
dc.contributor.author Makitie, Antti A.
dc.date.accessioned 2017-11-11T22:05:16Z
dc.date.available 2021-12-17T18:48:33Z
dc.date.issued 2016-11
dc.identifier.citation Vähämurto , P , Silventoinen , K , Vento , S , Karjalainen-Lindsberg , M-L , Haapaniemi , A , Back , L , Mannisto , S , Leppa , S & Makitie , A A 2016 , ' Clinical findings of extranodal SNT lymphoid malignancies in a four-decade single-centre series ' , European Archives of Oto-Rhino-Laryngology , vol. 273 , no. 11 , pp. 3839-3845 . https://doi.org/10.1007/s00405-016-3992-7
dc.identifier.other PURE: 71303363
dc.identifier.other PURE UUID: 9ce2e4c8-91fe-40ea-ae9a-7ad604ff7a71
dc.identifier.other WOS: 000385202600047
dc.identifier.other Scopus: 84961675396
dc.identifier.other ORCID: /0000-0002-8265-511X/work/29954206
dc.identifier.uri http://hdl.handle.net/10138/228495
dc.description.abstract Sinonasally located lymphoid malignancies are rare lesions with first symptoms similar to other obstructive conditions. Additionally, they often coexist with nasal inflammation and mucosal necrosis. Therefore, time from the first symptoms to diagnosis tends to be long. Awareness and early diagnosis of this disease entity could improve treatment outcome. Altogether, 142 patients with sinonasal or nasopharyngeal (i.e. sinonasal tract, SNT) lymphoid malignancies, diagnosed and treated at the Helsinki University Hospital, during a 39-year period from 1975 to 2013, were retrospectively reviewed. There were 90 males (63 %) and 52 females (37 %) with a median age of 64 years (range 26-92). Eighty-four percent of the patients had primary diseases and 16 % had relapses of lymphoid malignancies primarily diagnosed at other locations. The mean duration of symptoms prior to diagnosis was 4.8 months (range 0.5-24). The most common histological entity was diffuse large B-cell lymphoma (43 %), followed by plasmacytoma (18 %). The most common location was nasopharynx (58 %) followed by nasal cavity (44 %) and paranasal sinuses (35 %). Sixty-nine percent of the lesions were at a single anatomic location of the sinonasal tract. Fifty-two percent of the cases were of Ann Arbor Stage I. Lymphoid malignancies form an important and diverse group in the differential diagnosis of SNT tumours. They most often present with general obstructive nasal symptoms due to tumour location. Most of them are primary lesions, highlighting the importance of an accurate diagnosis as early as possible. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof European Archives of Oto-Rhino-Laryngology
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Diffuse large B-cell lymphoma
dc.subject Lymphoid malignancies
dc.subject Incidence
dc.subject Ann Arbor classification
dc.subject Sinonasal lymphoma
dc.subject Extranodal lymphoma
dc.subject Tumour
dc.subject NON-HODGKINS-LYMPHOMA
dc.subject LARGE B-CELL
dc.subject SINONASAL TRACT
dc.subject NASAL CAVITY
dc.subject PARANASAL SINUSES
dc.subject EPIDEMIOLOGY
dc.subject 3125 Otorhinolaryngology, ophthalmology
dc.title Clinical findings of extranodal SNT lymphoid malignancies in a four-decade single-centre series en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Korva-, nenä- ja kurkkutautien klinikka
dc.contributor.organization Department of Ophthalmology and Otorhinolaryngology
dc.contributor.organization Department of Pathology
dc.contributor.organization Medicum
dc.contributor.organization Research Programs Unit
dc.contributor.organization Department of Oncology
dc.contributor.organization Sirpa Marianne Leppä / Principal Investigator
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1007/s00405-016-3992-7
dc.relation.issn 0937-4477
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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