Does securin expression have significance in prognostication of oral tongue cancer? A pilot study

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Heikkinen , I , Almangush , A , Hagström , J , Bello , I O , Kauppila , J H , Mäkinen , L , Haglund , C , Nieminen , P , Salo , T & Leivo , I 2016 , ' Does securin expression have significance in prognostication of oral tongue cancer? A pilot study ' , European Archives of Oto-Rhino-Laryngology , vol. 273 , no. 11 , pp. 3905-3911 . https://doi.org/10.1007/s00405-016-3964-y

Title: Does securin expression have significance in prognostication of oral tongue cancer? A pilot study
Author: Heikkinen, Ilkka; Almangush, Alhadi; Hagström, Jaana; Bello, Ibrahim O.; Kauppila, Joonas H.; Mäkinen, Laura; Haglund, Caj; Nieminen, Pentti; Salo, Tuula; Leivo, Ilmo
Other contributor: University of Helsinki, Medicum
University of Helsinki, Department of Pathology
University of Helsinki, Research Programs Unit
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Department of Pathology









Date: 2016-11
Language: eng
Number of pages: 7
Belongs to series: European Archives of Oto-Rhino-Laryngology
ISSN: 0937-4477
DOI: https://doi.org/10.1007/s00405-016-3964-y
URI: http://hdl.handle.net/10138/228575
Abstract: The proliferation marker, securin, is involved in the progression of many carcinomas. However, its expression in oral tongue squamous cell carcinoma (OTSCC) has not been previously studied. We examined securin expression by immunohistochemistry in OTSCC. A total of 93 cases treated for OTSCC were included in this study. Expression of securin in OTSCC was studied by immunohistochemistry of tissue microarrays (52 cases) and routine tumor sections (41 cases). Securin overexpression is significantly associated with higher tumor grade (P = 0.03). Overexpression of securin was observed more frequently in advanced stages of OTSCC than in earlier stages but the difference was not statistically significant. These findings suggest that overexpression of securin in OTSCC may be important during progression of this cancer. No significant association was found between securin expression and the prognosis of OTSCC.
Subject: Oral tongue squamous cell carcinoma
Prognosis
Securin
Expression
SQUAMOUS-CELL CARCINOMA
TUMOR TRANSFORMING GENE
BREAST-CANCER
POOR-PROGNOSIS
OVEREXPRESSION
SURVIVAL
PTTG1
ANEUPLOIDY
APOPTOSIS
CDC20
3125 Otorhinolaryngology, ophthalmology
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