Periconception endogenous and exogenous maternal sex steroid hormones and risk of asthma and allergy in offspring : protocol for a systematic review and meta-analysis

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dc.contributor.author Talovic, Merhunisa
dc.contributor.author Sheikh, Aziz
dc.contributor.author McCleary, Nicola
dc.contributor.author Erkkola, Maijaliisa
dc.contributor.author Kaila, Minna
dc.contributor.author Virtanen, Suvi M.
dc.contributor.author Nwaru, Bright I.
dc.date.accessioned 2017-11-17T10:27:01Z
dc.date.available 2017-11-17T10:27:01Z
dc.date.issued 2017-07
dc.identifier.citation Talovic , M , Sheikh , A , McCleary , N , Erkkola , M , Kaila , M , Virtanen , S M & Nwaru , B I 2017 , ' Periconception endogenous and exogenous maternal sex steroid hormones and risk of asthma and allergy in offspring : protocol for a systematic review and meta-analysis ' , BMJ Open , vol. 7 , no. 7 , 014637 . https://doi.org/10.1136/bmjopen-2016-014637
dc.identifier.other PURE: 93823406
dc.identifier.other PURE UUID: b484ca95-1f26-46aa-91c5-4636f540a7a7
dc.identifier.other WOS: 000410203700048
dc.identifier.other Scopus: 85024394411
dc.identifier.other ORCID: /0000-0002-6966-1523/work/39204285
dc.identifier.uri http://hdl.handle.net/10138/228590
dc.description.abstract Introduction Pregnancy is associated with several hormonal changes which influence the developing fetus. Variations in maternal endogenous hormones and prepregnancy use of hormonal preparations have been linked to asthma and allergy in the offspring, but findings are inconsistent. We plan to undertake a systematic review to synthesise the evidence on the association between endogenous and exogenous maternal sex hormones and the risk of asthma and allergy in the offspring. Methods and analysis We will search Medline, Embase, Cochrane Library, Institute of Scientific Information Web of Science, Cumulative Index of Nursing and Allied Health, Scopus, Google Scholar, Allied and Complementary Medicine Database, Global Health, Psychological Information (PsycINFO), Centre for Agriculture and Bioscience (CAB) International and WHO Global Health Library from inception until 2016 to identify relevant studies on the topic. Additional studies will be identified by searching databases of proceedings of international conferences, contacting international experts in the field and searching the references cited in identified studies. We will include analytical epidemiological studies. Two researchers will independently screen identified studies, undertake data extraction and assess risk of bias in eligible studies, while a third reviewer will arbitrate any disagreement. We will use the Effective Public Health Practice Project tool to assess the risk of bias in the studies. We will perform a random-effects meta-analysis to synthesise the evidence. We will use the Grading of Recommendations Assessment, Development and Evaluation approach to rate the strength and quality of the overall evidence with respect to each outcome. Ethics and dissemination Ethical approval is not required since the study is a systematic review of published literature. Our findings will be reported in a peer-reviewed scientific journal. en
dc.format.extent 4
dc.language.iso eng
dc.relation.ispartof BMJ Open
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject ORAL-CONTRACEPTIVE USE
dc.subject PREGNANCY
dc.subject DISEASES
dc.subject RHINITIS
dc.subject PILLS
dc.subject BIAS
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Periconception endogenous and exogenous maternal sex steroid hormones and risk of asthma and allergy in offspring : protocol for a systematic review and meta-analysis en
dc.type Review Article
dc.contributor.organization Department of Food and Nutrition
dc.contributor.organization Maijaliisa Erkkola / Principal Investigator
dc.contributor.organization University of Helsinki
dc.contributor.organization Clinicum
dc.contributor.organization Department of Public Health
dc.contributor.organization Children's Hospital
dc.contributor.organization Nutrition Science
dc.contributor.organization HUS Psychiatry
dc.contributor.organization Teachers' Academy
dc.contributor.organization Family nutrition and wellbeing
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1136/bmjopen-2016-014637
dc.relation.issn 2044-6055
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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