Long working hours as a risk factor for atrial fibrillation : a multi-cohort study

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Kivimaki , M , Nyberg , S T , Batty , G D , Kawachi , I , Jokela , M , Alfredsson , L , Bjorner , J B , Borritz , M , Burr , H , Dragano , N , Fransson , E I , Heikkila , K , Knutsson , A , Koskenvuo , M , Kumari , M , Madsen , I E H , Nielsen , M L , Nordin , M , Oksanen , T , Pejtersen , J H , Pentti , J , Rugulies , R , Salo , P , Shipley , M J , Suominen , S , Theorell , T , Vahtera , J , Westerholm , P , Westerlund , H , Steptoe , A , Singh-Manoux , A , Hamer , M , Ferrie , J E , Virtanen , M , Tabak , A G & IPD-Work Consortium 2017 , ' Long working hours as a risk factor for atrial fibrillation : a multi-cohort study ' , European Heart Journal , vol. 38 , no. 34 , pp. 2621-2628 . https://doi.org/10.1093/eurheartj/ehx324

Title: Long working hours as a risk factor for atrial fibrillation : a multi-cohort study
Author: Kivimaki, Mika; Nyberg, Solja T.; Batty, G. David; Kawachi, Ichiro; Jokela, Markus; Alfredsson, Lars; Bjorner, Jakob B.; Borritz, Marianne; Burr, Hermann; Dragano, Nico; Fransson, Eleonor I.; Heikkila, Katriina; Knutsson, Anders; Koskenvuo, Markku; Kumari, Meena; Madsen, Ida E. H.; Nielsen, Martin L.; Nordin, Maria; Oksanen, Tuula; Pejtersen, Jan H.; Pentti, Jaana; Rugulies, Reiner; Salo, Paula; Shipley, Martin J.; Suominen, Sakari; Theorell, Tores; Vahtera, Jussi; Westerholm, Peter; Westerlund, Hugo; Steptoe, Andrew; Singh-Manoux, Archana; Hamer, Mark; Ferrie, Jane E.; Virtanen, Marianna; Tabak, Adam G.; IPD-Work Consortium
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Medicum
University of Helsinki, Markku Koskenvuo / Principal Investigator
University of Helsinki, Department of Public Health
Date: 2017-09-07
Language: eng
Number of pages: 8
Belongs to series: European Heart Journal
ISSN: 0195-668X
URI: http://hdl.handle.net/10138/228656
Abstract: Aims Studies suggest that people who work long hours are at increased risk of stroke, but the association of long working hours with atrial fibrillation, the most common cardiac arrhythmia and a risk factor for stroke, is unknown. We examined the risk of atrial fibrillation in individuals working long hours (>= 55 per week) and those working standard 35-40 h/week. Methods and results In this prospective multi-cohort study from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium, the study population was 85 494 working men and women (mean age 43.4 years) with no recorded atrial fibrillation. Working hours were assessed at study baseline (1991-2004). Mean follow-up for incident atrial fibrillation was 10 years and cases were defined using data on electrocardiograms, hospital records, drug reimbursement registers, and death certificates. We identified 1061 new cases of atrial fibrillation (10-year cumulative incidence 12.4 per 1000). After adjustment for age, sex and socioeconomic status, individuals working long hours had a 1.4-fold increased risk of atrial fibrillation compared with those working standard hours (hazard ratio = 1.42, 95% CI= 1.13-1.80, P= 0.003). There was no significant heterogeneity between the cohort-specific effect estimates (I-2= 0%, P = 0.66) and the finding remained after excluding participants with coronary heart disease or stroke at baseline or during the follow-up (N= 2006, hazard ratio= 1.36, 95% CI= 1.05-1.76, P = 0.0180). Adjustment for potential confounding factors, such as obesity, risky alcohol use and high blood pressure, had little impact on this association. Conclusion Individuals who worked long hours were more likely to develop atrial fibrillation than those working standard hours.
Subject: Atrial fibrillation
Life stress
Risk factors
Cohort study
CORONARY-HEART-DISEASE
MYOCARDIAL-INFARCTION
METAANALYSIS
POPULATION
3142 Public health care science, environmental and occupational health
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