Brain activation induced by chronic psychosocial stress in mice

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Laine , M A , Sokolowska , E , Dudek , M , Callan , S-A , Hyytia , P & Hovatta , I 2017 , ' Brain activation induced by chronic psychosocial stress in mice ' , Scientific Reports , vol. 7 , 15061 . https://doi.org/10.1038/s41598-017-15422-5

Title: Brain activation induced by chronic psychosocial stress in mice
Author: Laine, Mikaela A.; Sokolowska, Ewa; Dudek, Mateusz; Callan, Saija-Anita; Hyytia, Petri; Hovatta, Iiris
Other contributor: University of Helsinki, Biosciences
University of Helsinki, Biosciences
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Biosciences






Date: 2017-11-08
Language: eng
Number of pages: 11
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-017-15422-5
URI: http://hdl.handle.net/10138/228796
Abstract: Chronic psychosocial stress is a well-established risk factor for neuropsychiatric diseases. Abnormalities in brain activity have been demonstrated in patients with stress-related disorders. Global brain activation patterns during chronic stress exposure are less well understood but may have strong modifying effects on specific brain circuits and thereby influence development of stress-related pathologies. We determined neural activation induced by chronic social defeat stress, a mouse model of psychosocial stress. To assess chronic activation with an unbiased brain-wide focus we used manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemical staining of Delta FOSB, a transcription factor induced by repeated neural activity. One week after 10-day social defeat we observed significantly more activation in several brain regions known to regulate depressive and anxiety-like behaviour, including the prefrontal cortex, bed nucleus of stria terminalis, ventral hippocampus and periaqueductal grey in stressed compared to control mice. We further established that the correlation of Delta FOSB positive cells between specific brain regions was altered following chronic social defeat. Chronic activation of these neural circuits may relate to persistent brain activity changes occurring during chronic psychosocial stress exposure, with potential relevance for the development of anxiety and depression in humans.
Subject: ALCOHOL-PREFERRING RATS
MANGANESE-ENHANCED MRI
DELTA-FOSB
PREFRONTAL CORTEX
FUNCTIONAL CONNECTIVITY
MAJOR DEPRESSION
STRIA TERMINALIS
SOCIAL DEFEAT
RISK-FACTORS
ANXIETY
3111 Biomedicine
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