Reproductive profiles and risk of breast cancer subtypes : a multi-center case-only study

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Brouckaert , O , Rudolph , A , Laenen , A , Keeman , R , Bolla , M K , Wang , Q , Soubry , A , Wildiers , H , Andrulis , I L , Arndt , V , Beckmann , M W , Benitez , J , Blomqvist , C , Bojesen , S E , Brauch , H , Brennan , P , Brenner , H , Chenevix-Trench , G , Choi , J-Y , Cornelissen , S , Couch , F J , Cox , A , Cross , S S , Czene , K , Eriksson , M , Fasching , P A , Figueroa , J , Flyger , H , Giles , G G , Gonzalez-Neira , A , Guenel , P , Hall , P , Hollestelle , A , Hopper , J L , Ito , H , Jones , M , Kang , D , Knight , J A , Kosma , V-M , Li , J , Lindblom , A , Lilyquist , J , Lophatananon , A , Mannermaa , A , Manoukian , S , Margolin , S , Matsuo , K , Muir , K , Nevanlinna , H , Peterlongo , P & KConFab 2017 , ' Reproductive profiles and risk of breast cancer subtypes : a multi-center case-only study ' , Breast Cancer Research , vol. 19 , 119 .

Title: Reproductive profiles and risk of breast cancer subtypes : a multi-center case-only study
Author: Brouckaert, Olivier; Rudolph, Anja; Laenen, Annouschka; Keeman, Renske; Bolla, Manjeet K.; Wang, Qin; Soubry, Adelheid; Wildiers, Hans; Andrulis, Irene L.; Arndt, Volker; Beckmann, Matthias W.; Benitez, Javier; Blomqvist, Carl; Bojesen, Stig E.; Brauch, Hiltrud; Brennan, Paul; Brenner, Hermann; Chenevix-Trench, Georgia; Choi, Ji-Yeob; Cornelissen, Sten; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Eriksson, Mikael; Fasching, Peter A.; Figueroa, Jonine; Flyger, Henrik; Giles, Graham G.; Gonzalez-Neira, Anna; Guenel, Pascal; Hall, Per; Hollestelle, Antoinette; Hopper, John L.; Ito, Hidemi; Jones, Michael; Kang, Daehee; Knight, Julia A.; Kosma, Veli-Matti; Li, Jingmei; Lindblom, Annika; Lilyquist, Jenna; Lophatananon, Artitaya; Mannermaa, Arto; Manoukian, Siranoush; Margolin, Sara; Matsuo, Keitaro; Muir, Kenneth; Nevanlinna, Heli; Peterlongo, Paolo; KConFab
Contributor organization: Department of Oncology
HUS Gynecology and Obstetrics
Department of Obstetrics and Gynecology
HUS Comprehensive Cancer Center
Date: 2017-11-07
Language: eng
Number of pages: 12
Belongs to series: Breast Cancer Research
ISSN: 1465-542X
Abstract: Background: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. Methods: We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer Association Consortium (BCAC). In a case-only analysis, we used logistic regression to assess associations between reproductive factors and BC subtype compared to luminal A tumors as a reference. The interaction between age and parity in BC subtype risk was also tested, across all ages and, because age was modeled non-linearly, specifically at ages 35, 55 and 75 years. Results: Parous women were more likely to be diagnosed with triple negative BC (TNBC) than with luminal A BC, irrespective of age (OR for parity = 1.38, 95% CI 1.16-1.65, p = 0.0004; p for interaction with age = 0.076). Parous women were also more likely to be diagnosed with luminal and non-luminal HER2-like BCs and this effect was slightly more pronounced at an early age (p for interaction with age = 0.037 and 0. 030, respectively). For instance, women diagnosed at age 35 were 1.48 (CI 1.01-2.16) more likely to have luminal HER2-like BC than luminal A BC, while this association was not significant at age 75 (OR = 0.72, CI 0.45-1.14). While age at menarche was not significantly associated with BC subtype, increasing age at FFTP was non-linearly associated with TNBC relative to luminal A BC. An age at FFTP of 25 versus 20 years lowered the risk for TNBC (OR = 0.78, CI 0.70-0.88, p <0.0001), but this effect was not apparent at a later FFTP. Conclusions: Our main findings suggest that parity is associated with TNBC across all ages at BC diagnosis, whereas the association with luminal HER2-like BC was present only for early onset BC.
Subject: Breast cancer subtype
Age at breast cancer diagnosis
Age at first full-time pregnancy
Age at menarche
3122 Cancers
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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