Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) - an 11-Year Prospective Study

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Lallukka , S , Sadevirta , S , Kallio , M T , Luukkonen , P K , Zhou , Y , Hakkarainen , A , Lundbom , N , Orho-Melanders , M & Yki-Jarvinen , H 2017 , ' Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) - an 11-Year Prospective Study ' , Scientific Reports , vol. 7 , 14561 . https://doi.org/10.1038/s41598-017-14706-0

Title: Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) - an 11-Year Prospective Study
Author: Lallukka, Susanna; Sadevirta, Sanja; Kallio, Markus T.; Luukkonen, Panu K.; Zhou, You; Hakkarainen, Antti; Lundbom, Nina; Orho-Melanders, Marju; Yki-Jarvinen, Hannele
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Medicine
University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, Department of Medicine
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2017-11-06
Language: eng
Number of pages: 10
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/228873
Abstract: Liver fat can be non-invasively measured by proton magnetic resonance spectroscopy (H-1-MRS) and fibrosis estimated as stiffness using transient elastography (FibroScan). There are no longitudinal data on changes in liver fat in Europids or on predictors of liver stiffness using these methods. We determined liver fat (1H-MRS) and clinical characteristics including features of insulin resistance at baseline and after a median follow-up period of 11.3 (range 7.3-13.4) years in 97 Finnish subjects. Liver stiffness was measured at 11.3 years. Liver fat content decreased by 5% (p <0.05) over time. Values at baseline and 11.3 years were closely interrelated (r = 0.81, p <0.001). Baseline liver fat (OR 1.32; 95% CI: 1.15-1.50) and change in BMI (OR 1.67; 95% CI: 1.24-2.25) were independent predictors of liver fat at 11.3 years (AUROC 0.90; 95% CI: 0.83-0.96). Baseline liver fat (AUROC 0.84; 95% CI: 0.76-0.92) predicted liver fat at 11.3 years more accurately than routinely available parameters (AUROC 0.76; 95% CI: 0.65-0.86, p = 0.02). At 11.3 years, 29% of the subjects had increased liver stiffness. Baseline liver fat (OR 2.17; 95% CI: 1.05-4.46) was an independent predictor of increased liver stiffness. These data show that liver fat is more important than the associated metabolic abnormalities as the predictor of future liver fat and fibrosis.
Subject: MAGNETIC-RESONANCE-SPECTROSCOPY
FOLLOW-UP
INSULIN THERAPY
CONFERS SUSCEPTIBILITY
GENERAL-POPULATION
METABOLIC SYNDROME
HEPATIC STEATOSIS
ADIPOSE-TISSUE
VARIANT
GLUCOSE
3121 General medicine, internal medicine and other clinical medicine
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