Association between birthweight and later body mass index : an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

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Jelenkovic , A , Yokoyama , Y , Sund , R , Pietilainen , K H , Hur , Y-M , Willemsen , G , Bartels , M , van Beijsterveldt , T C E M , Ooki , S , Saudino , K J , Stazi , M A , Fagnani , C , D'Ippolito , C , Nelson , T L , Whitfield , K E , Knafo-Noam , A , Mankuta , D , Abramson , L , Heikkila , K , Cutler , T L , Hopper , J L , Wardle , J , Llewellyn , C H , Fisher , A , Corley , R P , Huibregtse , B M , Derom , C A , Vlietinck , R F , Loos , R J F , Bjerregaard-Andersen , M , Beck-Nielsen , H , Sodemann , M , Tarnoki , A D , LTarnoki , D , Burt , S A , Klump , K L , Ordonana , J R , Sanchez-Romera , J F , Colodro-Conde , L , Dubois , L , Boivin , M , Brendgen , M , Dionne , G , Vitaro , F , Harris , J R , Brandt , L , Nilsen , T S , Craig , J M , Saffery , R , Rasmussen , F , Tynelius , P , Bayasgalan , G , Narandalai , D , Haworth , C M A , Plomin , R , Ji , F , Ning , F , Pang , Z , Rebato , E , Krueger , R F , Mcgue , M , Pahlen , S , Boomsma , D I , Sorensen , T I A , Kaprio , J & Silventoinen , K 2017 , ' Association between birthweight and later body mass index : an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project ' , International Journal of Epidemiology , vol. 46 , no. 5 , pp. 1488-1498 .

Title: Association between birthweight and later body mass index : an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project
Author: Jelenkovic, Aline; Yokoyama, Yoshie; Sund, Reijo; Pietilainen, Kirsi H.; Hur, Yoon-Mi; Willemsen, Gonneke; Bartels, Meike; van Beijsterveldt, Toos C. E. M.; Ooki, Syuichi; Saudino, Kimberly J.; Stazi, Maria A.; Fagnani, Corrado; D'Ippolito, Cristina; Nelson, Tracy L.; Whitfield, Keith E.; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Heikkila, Kauko; Cutler, Tessa L.; Hopper, John L.; Wardle, Jane; Llewellyn, Clare H.; Fisher, Abigail; Corley, Robin P.; Huibregtse, Brooke M.; Derom, Catherine A.; Vlietinck, Robert F.; Loos, Ruth J. F.; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Tarnoki, Adam D.; LTarnoki, David; Burt, S. Alexandra; Klump, Kelly L.; Ordonana, Juan R.; Sanchez-Romera, Juan F.; Colodro-Conde, Lucia; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Harris, Jennifer R.; Brandt, Lngunn; Nilsen, Thomas Sevenius; Craig, Jeffrey M.; Saffery, Richard; Rasmussen, Finn; Tynelius, Per; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Haworth, Claire M. A.; Plomin, Robert; Ji, Fuling; Ning, Feng; Pang, Zengchang; Rebato, Esther; Krueger, Robert F.; Mcgue, Matt; Pahlen, Shandell; Boomsma, Dorret I.; Sorensen, Thorkild I. A.; Kaprio, Jaakko; Silventoinen, Karri
Contributor organization: Department of Social Research (2010-2017)
Centre for Social Data Science, CSDS
Diabetes and Obesity Research Program
Research Programs Unit
Endokrinologian yksikkö
Department of Medicine
Institute for Molecular Medicine Finland
Department of Public Health
University of Helsinki
Center for Population, Health and Society
Population Research Unit (PRU)
HUS Abdominal Center
Genetic Epidemiology
Date: 2017-10
Language: eng
Number of pages: 11
Belongs to series: International Journal of Epidemiology
ISSN: 0300-5771
Abstract: Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses. Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m(2) higher BMI (P <0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m(2) per kg birthweight, P <0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood. Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.
Subject: birthweight
body mass index
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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