Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

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Anastasina , M , Le May , N , Bugai , A , Fu , Y , Soderholm , S , Gaelings , L , Ohman , T , Tynell , J , Kyttanen , S , Barboric , M , Nyman , T A , Matikainen , S , Julkunen , I , Butcher , S J , Egly , J-M & Kainov , D E 2016 , ' Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes ' , Biochimica et Biophysica Acta. Gene Regulatory Mechanisms , vol. 1859 , no. 11 , pp. 1440-1448 . https://doi.org/10.1016/j.bbagrm.2016.09.005

Title: Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes
Author: Anastasina, Maria; Le May, Nicolas; Bugai, Andrii; Fu, Yu; Soderholm, Sandra; Gaelings, Lana; Ohman, Tiina; Tynell, Janne; Kyttanen, Suvi; Barboric, Matjaz; Nyman, Tuula A.; Matikainen, Sampsa; Julkunen, Ilkka; Butcher, Sarah J.; Egly, Jean-Marc; Kainov, Denis E.
Contributor organization: Institute of Biotechnology
Institute for Molecular Medicine Finland
Macromolecular structure and function
Medicum
Department of Biochemistry and Developmental Biology
Biosciences
Denis Kainov / Principal Investigator
Molecular Systems Biology
Date: 2016-11
Language: eng
Number of pages: 9
Belongs to series: Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
ISSN: 1874-9399
DOI: https://doi.org/10.1016/j.bbagrm.2016.09.005
URI: http://hdl.handle.net/10138/229281
Abstract: Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication. (C) 2016 Elsevier B.V. All rights reserved.
Subject: 3111 Biomedicine
Regulation of gene expression
Influenza A virus
Innate immunity
Antiviral responses
Viral counter-responses
DOUBLE-STRANDED-RNA
A VIRUS
INDUCIBLE GTPASES
VIRAL-INFECTIONS
EPITHELIAL-CELLS
STRUCTURAL BASIS
INNATE IMMUNITY
B VIRUSES
INTERFERON
EXPRESSION
1183 Plant biology, microbiology, virology
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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