Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

Show full item record



Permalink

http://hdl.handle.net/10138/229281

Citation

Anastasina , M , Le May , N , Bugai , A , Fu , Y , Soderholm , S , Gaelings , L , Ohman , T , Tynell , J , Kyttanen , S , Barboric , M , Nyman , T A , Matikainen , S , Julkunen , I , Butcher , S J , Egly , J-M & Kainov , D E 2016 , ' Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes ' Biochimica et Biophysica Acta. Gene Regulatory Mechanisms , vol. 1859 , no. 11 , pp. 1440-1448 . DOI: 10.1016/j.bbagrm.2016.09.005

Title: Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes
Author: Anastasina, Maria; Le May, Nicolas; Bugai, Andrii; Fu, Yu; Soderholm, Sandra; Gaelings, Lana; Ohman, Tiina; Tynell, Janne; Kyttanen, Suvi; Barboric, Matjaz; Nyman, Tuula A.; Matikainen, Sampsa; Julkunen, Ilkka; Butcher, Sarah J.; Egly, Jean-Marc; Kainov, Denis E.
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Department of Biochemistry and Developmental Biology
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute of Biotechnology
University of Helsinki, Department of Biochemistry and Developmental Biology
University of Helsinki, Institute of Biotechnology
University of Helsinki, Clinicum
University of Helsinki, Biosciences
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2016-11
Number of pages: 9
Belongs to series: Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
ISSN: 1874-9399
URI: http://hdl.handle.net/10138/229281
Abstract: Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication. (C) 2016 Elsevier B.V. All rights reserved.
Subject: 3111 Biomedicine
Regulation of gene expression
Influenza A virus
Innate immunity
Antiviral responses
Viral counter-responses
DOUBLE-STRANDED-RNA
A VIRUS
INDUCIBLE GTPASES
VIRAL-INFECTIONS
EPITHELIAL-CELLS
STRUCTURAL BASIS
INNATE IMMUNITY
B VIRUSES
INTERFERON
EXPRESSION
1183 Plant biology, microbiology, virology
1182 Biochemistry, cell and molecular biology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S1874939916301900_main.pdf 1.333Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record