Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes
Permalink
Citation
Anastasina , M , Le May , N , Bugai , A , Fu , Y , Soderholm , S , Gaelings , L , Ohman , T , Tynell , J , Kyttanen , S , Barboric , M , Nyman , T A , Matikainen , S , Julkunen , I , Butcher , S J , Egly , J-M & Kainov , D E 2016 , ' Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes ' , Biochimica et Biophysica Acta. Gene Regulatory Mechanisms , vol. 1859 , no. 11 , pp. 1440-1448 . https://doi.org/10.1016/j.bbagrm.2016.09.005
| Title: | Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes |
| Author: | Anastasina, Maria; Le May, Nicolas; Bugai, Andrii; Fu, Yu; Soderholm, Sandra; Gaelings, Lana; Ohman, Tiina; Tynell, Janne; Kyttanen, Suvi; Barboric, Matjaz; Nyman, Tuula A.; Matikainen, Sampsa; Julkunen, Ilkka; Butcher, Sarah J.; Egly, Jean-Marc; Kainov, Denis E. |
| Contributor organization: | Institute of Biotechnology Institute for Molecular Medicine Finland Macromolecular structure and function Medicum Department of Biochemistry and Developmental Biology Biosciences Denis Kainov / Principal Investigator Molecular Systems Biology |
| Date: | 2016-11 |
| Language: | eng |
| Number of pages: | 9 |
| Belongs to series: | Biochimica et Biophysica Acta. Gene Regulatory Mechanisms |
| ISSN: | 1874-9399 |
| DOI: | https://doi.org/10.1016/j.bbagrm.2016.09.005 |
| URI: | http://hdl.handle.net/10138/229281 |
| Abstract: | Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication. (C) 2016 Elsevier B.V. All rights reserved. |
| Subject: |
3111 Biomedicine
Regulation of gene expression Influenza A virus Innate immunity Antiviral responses Viral counter-responses DOUBLE-STRANDED-RNA A VIRUS INDUCIBLE GTPASES VIRAL-INFECTIONS EPITHELIAL-CELLS STRUCTURAL BASIS INNATE IMMUNITY B VIRUSES INTERFERON EXPRESSION 1183 Plant biology, microbiology, virology 1182 Biochemistry, cell and molecular biology |
| Peer reviewed: | Yes |
| Usage restriction: | openAccess |
| Self-archived version: | publishedVersion |
Files in this item
Total number of downloads: Loading...
| Files | Size | Format | View |
|---|---|---|---|
| 1_s2.0_S1874939916301900_main.pdf | 1.333Mb |
View/ |
This item appears in the following Collection(s)
-
Articles from TUHAT CRIS [50505]