Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes
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Anastasina , M , Le May , N , Bugai , A , Fu , Y , Soderholm , S , Gaelings , L , Ohman , T , Tynell , J , Kyttanen , S , Barboric , M , Nyman , T A , Matikainen , S , Julkunen , I , Butcher , S J , Egly , J-M & Kainov , D E 2016 , ' Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes ' Biochimica et Biophysica Acta. Gene Regulatory Mechanisms , vol. 1859 , no. 11 , pp. 1440-1448 . DOI: 10.1016/j.bbagrm.2016.09.005
| Title: | Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes |
| Author: | Anastasina, Maria; Le May, Nicolas; Bugai, Andrii; Fu, Yu; Soderholm, Sandra; Gaelings, Lana; Ohman, Tiina; Tynell, Janne; Kyttanen, Suvi; Barboric, Matjaz; Nyman, Tuula A.; Matikainen, Sampsa; Julkunen, Ilkka; Butcher, Sarah J.; Egly, Jean-Marc; Kainov, Denis E. |
| Contributor: | University of Helsinki, Institute of Biotechnology University of Helsinki, Department of Biochemistry and Developmental Biology University of Helsinki, Institute for Molecular Medicine Finland University of Helsinki, Institute of Biotechnology University of Helsinki, Institute for Molecular Medicine Finland University of Helsinki, Institute of Biotechnology University of Helsinki, Department of Biochemistry and Developmental Biology University of Helsinki, Institute of Biotechnology University of Helsinki, Clinicum University of Helsinki, Biosciences University of Helsinki, Institute for Molecular Medicine Finland |
| Date: | 2016-11 |
| Number of pages: | 9 |
| Belongs to series: | Biochimica et Biophysica Acta. Gene Regulatory Mechanisms |
| ISSN: | 1874-9399 |
| URI: | http://hdl.handle.net/10138/229281 |
| Abstract: | Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication. (C) 2016 Elsevier B.V. All rights reserved. |
| Subject: |
3111 Biomedicine
Regulation of gene expression Influenza A virus Innate immunity Antiviral responses Viral counter-responses DOUBLE-STRANDED-RNA A VIRUS INDUCIBLE GTPASES VIRAL-INFECTIONS EPITHELIAL-CELLS STRUCTURAL BASIS INNATE IMMUNITY B VIRUSES INTERFERON EXPRESSION 1183 Plant biology, microbiology, virology 1182 Biochemistry, cell and molecular biology |
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