High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma

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Seppälä , M , Pohjola , K , Laranne , J , Rautiainen , M , Huhtala , H , Renkonen , R , Lemstrom , K , Paavonen , T & Toppila-Salmi , S 2016 , ' High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma ' , European Archives of Oto-Rhino-Laryngology , vol. 273 , no. 12 , pp. 4515-4524 . https://doi.org/10.1007/s00405-016-4150-y

Title: High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma
Author: Seppälä, Miia; Pohjola, Konsta; Laranne, Jussi; Rautiainen, Markus; Huhtala, Heini; Renkonen, Risto; Lemstrom, Karl; Paavonen, Timo; Toppila-Salmi, Sanna
Other contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Clinicum
University of Helsinki, Medicum








Date: 2016-12
Language: eng
Number of pages: 10
Belongs to series: European Archives of Oto-Rhino-Laryngology
ISSN: 0937-4477
DOI: https://doi.org/10.1007/s00405-016-4150-y
URI: http://hdl.handle.net/10138/229297
Abstract: Tongue cancer has a poor prognosis due to its early metastasis via lymphatic vessels. The present study aimed at evaluating lymphatic vessel density, relative density of lymphatic vessel, and diameter of lymphatic vessels and its predictive role in tongue cancer. Paraffin-embedded tongue and lymph node specimens (n = 113) were stained immunohistochemically with a polyclonal antibody von Willebrand factor, recognizing blood and lymphatic endothelium and with a monoclonal antibody podoplanin, recognizing lymphatic endothelium. The relative density of lymphatic vessels was counted by dividing the mean number of lymphatic vessels per microscopic field (podoplanin) by the mean number of all vessels (vWf) per microscopic field. The high relative density of lymphatic vessels (aeyen80 %) was associated with poor prognosis in tongue cancer. The relative density of lymphatic vessels predicted poor prognosis in the group of primary tumor size T1-T2 and in the group of non-metastatic cancer. The lymphatic vessel density and diameter of lymphatic vessels were not associated with tongue cancer survival. The relative density of lymphatic vessels might have clinically relevant prognostic impact. Further studies with increased number of patients are needed.
Subject: Tongue cancer
Head and neck cancer
Lymphatic vessels
Survival
Immunohistochemistry
VON-WILLEBRAND-FACTOR
ORAL TONGUE
TUMOR LYMPHANGIOGENESIS
PODOPLANIN EXPRESSION
MONOCLONAL-ANTIBODY
COLORECTAL-CANCER
GASTRIC-CANCER
NECK-CANCER
METASTASIS
INVASION
3111 Biomedicine
3125 Otorhinolaryngology, ophthalmology
3122 Cancers
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