Non-alcoholic Korsakoff syndrome in psychiatric patients with a history of undiagnosed Wernicke's encephalopathy

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Nikolakaros , G , Ilonen , T , Kurki , T , Paju , J , Papageorgiou , S G & Vataja , R 2016 , ' Non-alcoholic Korsakoff syndrome in psychiatric patients with a history of undiagnosed Wernicke's encephalopathy ' , Journal of the Neurological Sciences , vol. 370 , pp. 296-302 . https://doi.org/10.1016/j.jns.2016.09.025

Title: Non-alcoholic Korsakoff syndrome in psychiatric patients with a history of undiagnosed Wernicke's encephalopathy
Author: Nikolakaros, Georgios; Ilonen, Tuula; Kurki, Timo; Paju, Janina; Papageorgiou, Sokratis G.; Vataja, Risto
Contributor: University of Helsinki, Clinicum
Date: 2016-11-15
Language: eng
Number of pages: 7
Belongs to series: Journal of the Neurological Sciences
ISSN: 0022-510X
URI: http://hdl.handle.net/10138/229299
Abstract: Wernicke's encephalopathy is often undiagnosed, particularly in non-alcoholics. There are very few reports of non-alcoholic patients diagnosed with Korsakoff syndrome in the absence of a prior diagnosis of Wernicke's encephalopathy and no studies of diffusion tensor imaging in non-alcoholic Korsakoff syndrome. We report on three non-alcoholic psychiatric patients (all women) with long-term non-progressive memory impairment that developed after malnutrition accompanied by at least one of the three Wemicke's encephalopathy manifestations: ocular abnormalities, ataxia or unsteadiness, and an altered mental state or mild memory impairment. In neuropsychological examination, all patients had memory impairment, including intrusions. One patient had mild cerebellar vermis atrophy in MRI taken after the second episode of Wemicke's encephalopathy. The same patient had mild hypometabolism in the lateral cortex of the temporal lobes. Another patient had mild symmetrical atrophy and hypometabolism of the superior frontal lobes. Two patients were examined with diffusion tensor imaging. Reduced fractional anisotropy values were found in the corona radiata in two patients, and the uncinate fasciculus and the inferior longitudinal fasciculus in one patient. Our results suggest that non-alcoholic Korsakoff syndrome is underdiagnosed. Psychiatric patients with long-term memory impairment may have Korsakoff syndrome and, therefore, they should be evaluated for a history of previously undiagnosed Wernicke's encephalopathy. (C) 2016 Elsevier B.V. All rights reserved.
Subject: Diffusion tensor imaging
Korsakoff syndrome
Neuropsychological tests
Positron-emission tomography
Psychiatric treatment
Wernicke's encephalopathy
WHITE-MATTER MICROSTRUCTURE
AMNESIC SYNDROME
MEMORY
ABNORMALITIES
IMPAIRMENT
ALCOHOLISM
DIAGNOSIS
DISORDER
MANIFESTATIONS
DEFICIENCY
3124 Neurology and psychiatry
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