Non-alcoholic Korsakoff syndrome in psychiatric patients with a history of undiagnosed Wernicke's encephalopathy

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dc.contributor.author Nikolakaros, Georgios
dc.contributor.author Ilonen, Tuula
dc.contributor.author Kurki, Timo
dc.contributor.author Paju, Janina
dc.contributor.author Papageorgiou, Sokratis G.
dc.contributor.author Vataja, Risto
dc.date.accessioned 2017-12-10T22:07:37Z
dc.date.available 2021-12-17T18:47:22Z
dc.date.issued 2016-11-15
dc.identifier.citation Nikolakaros , G , Ilonen , T , Kurki , T , Paju , J , Papageorgiou , S G & Vataja , R 2016 , ' Non-alcoholic Korsakoff syndrome in psychiatric patients with a history of undiagnosed Wernicke's encephalopathy ' , Journal of the Neurological Sciences , vol. 370 , pp. 296-302 . https://doi.org/10.1016/j.jns.2016.09.025
dc.identifier.other PURE: 72657698
dc.identifier.other PURE UUID: f3176a6d-bc9b-442e-a4ec-6b6a476788b0
dc.identifier.other WOS: 000387627800061
dc.identifier.other Scopus: 84991325425
dc.identifier.uri http://hdl.handle.net/10138/229299
dc.description.abstract Wernicke's encephalopathy is often undiagnosed, particularly in non-alcoholics. There are very few reports of non-alcoholic patients diagnosed with Korsakoff syndrome in the absence of a prior diagnosis of Wernicke's encephalopathy and no studies of diffusion tensor imaging in non-alcoholic Korsakoff syndrome. We report on three non-alcoholic psychiatric patients (all women) with long-term non-progressive memory impairment that developed after malnutrition accompanied by at least one of the three Wemicke's encephalopathy manifestations: ocular abnormalities, ataxia or unsteadiness, and an altered mental state or mild memory impairment. In neuropsychological examination, all patients had memory impairment, including intrusions. One patient had mild cerebellar vermis atrophy in MRI taken after the second episode of Wemicke's encephalopathy. The same patient had mild hypometabolism in the lateral cortex of the temporal lobes. Another patient had mild symmetrical atrophy and hypometabolism of the superior frontal lobes. Two patients were examined with diffusion tensor imaging. Reduced fractional anisotropy values were found in the corona radiata in two patients, and the uncinate fasciculus and the inferior longitudinal fasciculus in one patient. Our results suggest that non-alcoholic Korsakoff syndrome is underdiagnosed. Psychiatric patients with long-term memory impairment may have Korsakoff syndrome and, therefore, they should be evaluated for a history of previously undiagnosed Wernicke's encephalopathy. (C) 2016 Elsevier B.V. All rights reserved. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Journal of the Neurological Sciences
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Diffusion tensor imaging
dc.subject Korsakoff syndrome
dc.subject Neuropsychological tests
dc.subject Positron-emission tomography
dc.subject Psychiatric treatment
dc.subject Wernicke's encephalopathy
dc.subject WHITE-MATTER MICROSTRUCTURE
dc.subject AMNESIC SYNDROME
dc.subject MEMORY
dc.subject ABNORMALITIES
dc.subject IMPAIRMENT
dc.subject ALCOHOLISM
dc.subject DIAGNOSIS
dc.subject DISORDER
dc.subject MANIFESTATIONS
dc.subject DEFICIENCY
dc.subject 3124 Neurology and psychiatry
dc.title Non-alcoholic Korsakoff syndrome in psychiatric patients with a history of undiagnosed Wernicke's encephalopathy en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Psychiatry
dc.contributor.organization HUS Psychiatry
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.jns.2016.09.025
dc.relation.issn 0022-510X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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