Germline variation in ADAMTSL1 is associated with prognosis following breast cancer treatment in young women

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Kadalayil , L , Khan , S , Nevanlinna , H , Fasching , P A , Couch , F J , Hopper , J L , Liu , J , Maishman , T , Durcan , L , Gerty , S , Blomqvist , C , Rack , B , Janni , W , Collins , A , Eccles , D & Tapper , W 2017 , ' Germline variation in ADAMTSL1 is associated with prognosis following breast cancer treatment in young women ' , Nature Communications , vol. 8 , 1632 . https://doi.org/10.1038/s41467-017-01775-y

Title: Germline variation in ADAMTSL1 is associated with prognosis following breast cancer treatment in young women
Author: Kadalayil, Latha; Khan, Sofia; Nevanlinna, Heli; Fasching, Peter A.; Couch, Fergus J.; Hopper, John L.; Liu, Jianjun; Maishman, Tom; Durcan, Lorraine; Gerty, Sue; Blomqvist, Carl; Rack, Brigitte; Janni, Wolfgang; Collins, Andrew; Eccles, Diana; Tapper, William
Contributor: University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Clinicum
Date: 2017-11-21
Language: eng
Number of pages: 12
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/229516
Abstract: To identify genetic variants associated with breast cancer prognosis we conduct a meta-analysis of overall survival (OS) and disease-free survival (DFS) in 6042 patients from four cohorts. In young women, breast cancer is characterized by a higher incidence of adverse pathological features, unique gene expression profiles and worse survival, which may relate to germline variation. To explore this hypothesis, we also perform survival analysis in 2315 patients aged
Subject: GENE-EXPRESSION
TUMOR PHENOTYPE
GENOME
RISK
AGE
SUSCEPTIBILITY
METHYLATION
ANNOTATION
VARIANTS
IDENTIFICATION
3123 Gynaecology and paediatrics
3122 Cancers
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