Measuring senescence rates of patients with end-stage renal disease while accounting for population heterogeneity : an analysis of data from the ERA-EDTA Registry

Show full item record



Permalink

http://hdl.handle.net/10138/229658

Citation

Koopman , J J E , Kramer , A , van Heemst , D , Asberg , A , Beuscart , J-B , Buturovic-Ponikvar , J , Collart , F , Couchoud , C G , Finne , P , Heaf , J G , Massy , Z A , De Meester , J M J , Palsson , R , Steenkamp , R , Traynor , J P , Jager , K J & Putter , H 2016 , ' Measuring senescence rates of patients with end-stage renal disease while accounting for population heterogeneity : an analysis of data from the ERA-EDTA Registry ' , Annals of Epidemiology , vol. 26 , no. 11 , pp. 773-779 . https://doi.org/10.1016/j.annepidem.2016.08.010

Title: Measuring senescence rates of patients with end-stage renal disease while accounting for population heterogeneity : an analysis of data from the ERA-EDTA Registry
Author: Koopman, Jacob J. E.; Kramer, Anneke; van Heemst, Diana; Asberg, Anders; Beuscart, Jean-Baptiste; Buturovic-Ponikvar, Jadranka; Collart, Frederic; Couchoud, Cecile G.; Finne, Patrik; Heaf, James G.; Massy, Ziad A.; De Meester, Johan M. J.; Palsson, Runolfur; Steenkamp, Retha; Traynor, Jamie P.; Jager, Kitty J.; Putter, Hein
Other contributor: University of Helsinki, Clinicum


Date: 2016-11
Language: eng
Number of pages: 7
Belongs to series: Annals of Epidemiology
ISSN: 1047-2797
DOI: https://doi.org/10.1016/j.annepidem.2016.08.010
URI: http://hdl.handle.net/10138/229658
Abstract: Purpose: Although a population's senescence rate is classically measured as the increase in mortality rate with age on a logarithmic scale, it may be more accurately measured as the increase on a linear scale. Patients on dialysis, who suffer from accelerated senescence, exhibit a smaller increase in their mortality rate on a logarithmic scale, but a larger increase on a linear scale than patients with a functioning kidney transplant. However, this comparison may be biased by population heterogeneity. Methods: Follow-up data on 323,308 patients on dialysis and 91,679 patients with a functioning kidney transplant were derived from the ERA-EDTA Registry. We measured the increases in their mortality rates using Gompertz frailty models that allow individual variation in this increase. Results: According to these models, the senescence rate measured as the increase in mortality rate on a logarithmic scale was smaller in patients on dialysis, while the senescence rate measured as the increase on a linear scale was larger in patients on dialysis than patients with a functioning kidney transplant. Conclusions: Also when accounting for population heterogeneity, a population's senescence rate is more accurately measured as the increase in mortality rate on a linear scale than a logarithmic scale. (C) 2016 Elsevier Inc. All rights reserved.
Subject: Aging
Dialysis
End-stage renal disease
Frailty
Gompertz model
Kidney transplantation
Mortality rate
Population heterogeneity
Senescence
Senescence rate
CHRONIC KIDNEY-DISEASE
MORTALITY
TRANSPLANTATION
DYNAMICS
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S1047279716302526_main.pdf 506.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record