Disease activity in and quality of life of patients with psoriatic arthritis mutilans : the Nordic PAM Study

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http://hdl.handle.net/10138/229741

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Lindqvist , U , Gudbjornsson , B , Iversen , L , Laasonen , L , Ejstrup , L , Ternowitz , T & Stahle , M 2017 , ' Disease activity in and quality of life of patients with psoriatic arthritis mutilans : the Nordic PAM Study ' , Scandinavian Journal of Rheumatology , vol. 46 , no. 6 , pp. 454-460 . https://doi.org/10.1080/03009742.2017.1278787

Title: Disease activity in and quality of life of patients with psoriatic arthritis mutilans : the Nordic PAM Study
Author: Lindqvist, U.; Gudbjornsson, B.; Iversen, L.; Laasonen, L.; Ejstrup, L.; Ternowitz, T.; Stahle, M.
Contributor: University of Helsinki, Clinicum
Date: 2017
Language: eng
Number of pages: 7
Belongs to series: Scandinavian Journal of Rheumatology
ISSN: 0300-9742
URI: http://hdl.handle.net/10138/229741
Abstract: Objective: To describe the social status and health-related quality of life of patients with psoriatic arthritis mutilans (PAM) in the Nordic countries.Method: Patients with at least one mutilated joint confirmed by radiology were studied. Disease activity involving joints and skin, physician-assessed disease activity, and patient's education and work status were recorded. Data from the 36-item Short Form Health Survey, Health Assessment Questionnaire and Dermatology Life Quality Index questionnaire were gathered and correlated with disease duration, pain, and general well-being (visual analogue scale). The controls were 58 Swedish patients with long-standing psoriatic arthritis sine PAM.Results: Sixty-seven patients were included. Patients with PAM had a protracted disease history (3314years) and disease onset at a relatively early age (30 +/- 12years). Overall inflammatory activity at inclusion was mild to moderate. The mean number of mutilated joints was 8.2 and gross deformity was found in 16% of patients. Forty per cent were treated with biological and 32% with conventional synthetic disease-modifying anti-rheumatic drugs. Forty-two per cent had retired early or were on sick leave. Impaired functional capacity with little or no ability to perform self-care or everyday tasks was reported by 21% of the patients. Patients between 45 and 60years of age reported the most impaired quality of life in comparison to the control group.Conclusion: PAM seriously affects social functioning. Whether early recognition of PAM and new forms of therapy can improve disease outcome and quality of life remains to be studied.
Subject: HEALTH-ASSESSMENT QUESTIONNAIRE
RHEUMATOID-ARTHRITIS
INDEX DLQI
PREVALENCE
ONSET
AGE
PROGRESSION
REGISTER
SWEDEN
DAMAGE
3121 General medicine, internal medicine and other clinical medicine
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