Disease activity in and quality of life of patients with psoriatic arthritis mutilans : the Nordic PAM Study

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dc.contributor.author Lindqvist, U.
dc.contributor.author Gudbjornsson, B.
dc.contributor.author Iversen, L.
dc.contributor.author Laasonen, L.
dc.contributor.author Ejstrup, L.
dc.contributor.author Ternowitz, T.
dc.contributor.author Stahle, M.
dc.date.accessioned 2017-12-20T08:58:00Z
dc.date.available 2017-12-20T08:58:00Z
dc.date.issued 2017
dc.identifier.citation Lindqvist , U , Gudbjornsson , B , Iversen , L , Laasonen , L , Ejstrup , L , Ternowitz , T & Stahle , M 2017 , ' Disease activity in and quality of life of patients with psoriatic arthritis mutilans : the Nordic PAM Study ' , Scandinavian Journal of Rheumatology , vol. 46 , no. 6 , pp. 454-460 . https://doi.org/10.1080/03009742.2017.1278787
dc.identifier.other PURE: 95546370
dc.identifier.other PURE UUID: bc7f4ea0-ef82-4309-a005-226b2e5da4ea
dc.identifier.other WOS: 000415723100005
dc.identifier.other Scopus: 85012078091
dc.identifier.uri http://hdl.handle.net/10138/229741
dc.description.abstract Objective: To describe the social status and health-related quality of life of patients with psoriatic arthritis mutilans (PAM) in the Nordic countries.Method: Patients with at least one mutilated joint confirmed by radiology were studied. Disease activity involving joints and skin, physician-assessed disease activity, and patient's education and work status were recorded. Data from the 36-item Short Form Health Survey, Health Assessment Questionnaire and Dermatology Life Quality Index questionnaire were gathered and correlated with disease duration, pain, and general well-being (visual analogue scale). The controls were 58 Swedish patients with long-standing psoriatic arthritis sine PAM.Results: Sixty-seven patients were included. Patients with PAM had a protracted disease history (3314years) and disease onset at a relatively early age (30 +/- 12years). Overall inflammatory activity at inclusion was mild to moderate. The mean number of mutilated joints was 8.2 and gross deformity was found in 16% of patients. Forty per cent were treated with biological and 32% with conventional synthetic disease-modifying anti-rheumatic drugs. Forty-two per cent had retired early or were on sick leave. Impaired functional capacity with little or no ability to perform self-care or everyday tasks was reported by 21% of the patients. Patients between 45 and 60years of age reported the most impaired quality of life in comparison to the control group.Conclusion: PAM seriously affects social functioning. Whether early recognition of PAM and new forms of therapy can improve disease outcome and quality of life remains to be studied. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Scandinavian Journal of Rheumatology
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject INDEX DLQI
dc.subject PREVALENCE
dc.subject ONSET
dc.subject AGE
dc.subject PROGRESSION
dc.subject REGISTER
dc.subject SWEDEN
dc.subject DAMAGE
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Disease activity in and quality of life of patients with psoriatic arthritis mutilans : the Nordic PAM Study en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization HUS Medical Imaging Center
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1080/03009742.2017.1278787
dc.relation.issn 0300-9742
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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