Human Protoparvoviruses

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http://hdl.handle.net/10138/229925

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Vaisanen , E , Fu , Y , Hedman , K & Soderlund-Venermo , M 2017 , ' Human Protoparvoviruses ' , Viruses-Basel , vol. 9 , no. 11 , 354 . https://doi.org/10.3390/v9110354

Title: Human Protoparvoviruses
Author: Vaisanen, Elina; Fu, Yu; Hedman, Klaus; Soderlund-Venermo, Maria
Contributor: University of Helsinki, Department of Virology
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Medicum
Date: 2017-11
Language: eng
Number of pages: 13
Belongs to series: Viruses-Basel
ISSN: 1999-4915
URI: http://hdl.handle.net/10138/229925
Abstract: Next-generation sequencing and metagenomics have revolutionized the discovery of novel viruses. In recent years, three novel protoparvoviruses have been discovered in fecal samples of humans: bufavirus (BuV) in 2012, tusavirus (TuV) in 2014, and cutavirus (CuV) in 2016. BuV has since been studied the most, disclosing three genotypes that also represent serotypes. Besides one nasal sample, BuV DNA has been found exclusively in diarrheal feces, but not in non-diarrheal feces, suggesting a causal relationship. According to both geno- and seroprevalences, BuV appears to be the most common of the three novel protoparvoviruses, whereas TuV DNA has been found in only a single fecal sample, with antibody detection being equally rare. Moreover, the TuV sequence is closer to those of non-human protoparvoviruses, and so the evidence of TuV being a human virus is thus far insufficient. Interestingly, besides in feces, CuV has also been detected in skin biopsies of patients with cutaneous T-cell lymphoma and a patient with melanoma, while all other skin samples have tested PCR negative. Even if preliminary disease associations exist, the full etiological roles of these viruses in human disease are yet to be resolved.
Subject: human protoparvovirus
bufavirus
tusavirus
cutavirus
discovery
epidemiology
gastroenteritis
cutaneous T-cell lymphoma
emerging viruses
HUMAN BUFAVIRUS
ACUTE DIARRHEA
DOMESTIC PIGS
PARVOVIRUS
VIRUSES
FECES
IDENTIFICATION
RECOMBINATION
INFECTION
CHILDREN
3111 Biomedicine
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