The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy

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Heymans , S , Eriksson , U , Lehtonen , J & Cooper , L T 2016 , ' The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy ' Journal of the American College of Cardiology , vol. 68 , no. 21 , pp. 2348-2364 . DOI: 10.1016/j.jacc.2016.09.937

Title: The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy
Author: Heymans, Stephane; Eriksson, Urs; Lehtonen, Jukka; Cooper, Leslie T.
Contributor: University of Helsinki, Kimmo Kontula / Principal Investigator
Date: 2016-11-29
Language: eng
Number of pages: 17
Belongs to series: Journal of the American College of Cardiology
ISSN: 0735-1097
URI: http://hdl.handle.net/10138/230026
Abstract: Myocarditis is a diverse group of heart-specific immune processes classified by clinical and histopathological manifestations. Up to 40% of dilated cardiomyopathy is associated with inflammation or viral infection. Recent experimental studies revealed complex regulatory roles for several microribonucleic acids and T-cell and macrophage subtypes. Although the prevalence of myocarditis remained stable between 1990 and 2013 at about 22 per 100,000 people, overall mortality from cardiomyopathy and myocarditis has decreased since 2005. The diagnostic and prognostic value of cardiac magnetic resonance has increased with new, higher-sensitivity sequences. Positron emission tomography has emerged as a useful tool for diagnosis of cardiac sarcoidosis. The sensitivity of endomyocardial biopsy may be increased, especially in suspected sarcoidosis, by the use of electrogram guidance to target regions of abnormal signal. Investigational treatments on the basis of mechanistic advances are entering clinical trials. Revised management recommendations regarding athletic participation after acute myocarditis have heightened the importance of early diagnosis. (C) 2016 by the American College of Cardiology Foundation.
Subject: heart failure
inflammasomes
macrophages
microRNAs
sarcoidosis
t-lymphocyte subsets
viral infection
GIANT-CELL MYOCARDITIS
EXPERIMENTAL AUTOIMMUNE MYOCARDITIS
COXSACKIEVIRUS B3-INDUCED MYOCARDITIS
IDIOPATHIC DILATED CARDIOMYOPATHY
CHAGAS-HEART-DISEASE
CARDIOVASCULAR MAGNETIC-RESONANCE
LEFT-VENTRICULAR DYSFUNCTION
CLINICALLY SUSPECTED MYOCARDITIS
POSITRON-EMISSION-TOMOGRAPHY
ACUTE VIRAL MYOCARDITIS
3121 Internal medicine
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