Pilot Assessment of the Repeatability of Indocyanine Green Fluorescence Imaging and Correlation with Traditional Foot Perfusion Assessments

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Venermo , M , Settembre , N , Albäck , A , Vikatmaa , P , Aho , P -S , Lepantalo , M , Inoue , Y & Terasaki , H 2016 , ' Pilot Assessment of the Repeatability of Indocyanine Green Fluorescence Imaging and Correlation with Traditional Foot Perfusion Assessments ' , European Journal of Vascular and Endovascular Surgery , vol. 52 , no. 4 , pp. 527-533 . https://doi.org/10.1016/j.ejvs.2016.06.018

Title: Pilot Assessment of the Repeatability of Indocyanine Green Fluorescence Imaging and Correlation with Traditional Foot Perfusion Assessments
Author: Venermo, M.; Settembre, N.; Albäck, A.; Vikatmaa, P.; Aho, P. -S.; Lepantalo, M.; Inoue, Y.; Terasaki, H.
Contributor organization: Clinicum
Verisuonikirurgian yksikkö
Department of Surgery
Date: 2016-10
Language: eng
Number of pages: 7
Belongs to series: European Journal of Vascular and Endovascular Surgery
ISSN: 1078-5884
DOI: https://doi.org/10.1016/j.ejvs.2016.06.018
URI: http://hdl.handle.net/10138/230029
Abstract: Background: Ankle brachial index (ABI), toe pressures (TP), and transcutaneous oxygen pressure (TcPO2) are traditionally used in the assessment of critical limb ischemia (CLI). Indocyanine green (ICG) fluorescence imaging can be used to evaluate local circulation in the foot and to evaluate the severity of ischemia. This prospective study analyzed the suitability of a fluorescence imaging system (photodynamic eye [PDE]) in CLI. Material and methods: Forty-one patients with CLI were included. Of the patients, 66% had diabetes and there was an ischemic tissue lesion in 70% of the limbs. ABI, toe pressures, TcPO2 and ICG-fluorescence imaging (ICG-FI) were measured in each leg. To study the repeatability of the ICG-FI, each patient underwent the study twice. After the procedure, foot circulation was measured using a time-intensity curve, where T1/2 (the time needed to achieve half of the maximum fluorescence intensity) and PDE10 (increase of the intensity during the first 10 s) were determined. A time-intensity curve was plotted using the same areas as for the TcPO2 probes (n=123). Results: The mean ABI was 0.43, TP 21 mmHg, TcPO2 23 mmHg, T1/2 38 5, and PDE10 19 AU. Time-intensity curves were repeatable. In a Bland-Altman scatter plot, the 95% limits of agreement of PDE10 was 9.9 AU and the corresponding value of T1/2 was 14 s. Correlation between ABI and TP was significant (R=.73, p Conclusions: According to this pilot study, ICG-Fl with PDE can be used in the assessment of blood supply in the ischemic foot. (C) 2016 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
Subject: Critical limb ischemia
ABI
Toe pressure
TcPO2
Indocyanine-green fluorescence imaging
Diagnostics
Repeatability
LASER-DOPPLER
ANGIOGRAPHY
BLOOD
PRESSURES
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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