Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

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http://hdl.handle.net/10138/230325

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Peck , M W , Smith , T J , Anniballi , F , Austin , J W , Bano , L , Bradshaw , M , Cuervo , P , Cheng , L W , Derman , Y , Dorner , B G , Fisher , A , Hill , K K , Kalb , S R , Korkeala , H , Lindström , M , Lista , F , Luquez , C , Mazuet , C , Pirazzini , M , Popoff , M R , Rossetto , O , Rummel , A , Sesardic , D , Singh , B R & Stringer , S C 2017 , ' Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature ' , Toxins , vol. 9 , no. 1 , 38 . https://doi.org/10.3390/toxins9010038

Title: Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature
Author: Peck, Michael W.; Smith, Theresa J.; Anniballi, Fabrizio; Austin, John W.; Bano, Luca; Bradshaw, Marite; Cuervo, Paula; Cheng, Luisa W.; Derman, Yagmur; Dorner, Brigitte G.; Fisher, Audrey; Hill, Karen K.; Kalb, Suzanne R.; Korkeala, Hannu; Lindström, Miia; Lista, Florigio; Luquez, Carolina; Mazuet, Christelle; Pirazzini, Marco; Popoff, Michel R.; Rossetto, Ornella; Rummel, Andreas; Sesardic, Dorothea; Singh, Bal Ram; Stringer, Sandra C.
Contributor organization: Departments of Faculty of Veterinary Medicine
Food Hygiene and Environmental Health
Hannu Korkeala / Principal Investigator
Miia Lindström / Principal Investigator
Date: 2017-01
Language: eng
Number of pages: 21
Belongs to series: Toxins
ISSN: 2072-6651
DOI: https://doi.org/10.3390/toxins9010038
URI: http://hdl.handle.net/10138/230325
Abstract: Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss the clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future.
Subject: botulinum
botulism
neurotoxins
subtypes
Clostridium botulinum
guidelines
nomenclature
NONPROTEOLYTIC CLOSTRIDIUM-BOTULINUM
FRAGMENT LENGTH POLYMORPHISM
NUCLEOTIDE-SEQUENCE ANALYSIS
ANTIBODY-BASED IMMUNOASSAY
AMINO-ACID-SEQUENCE
INFANT BOTULISM
MONOCLONAL-ANTIBODIES
B NEUROTOXIN
GROUP-I
GENETIC DIVERSITY
1183 Plant biology, microbiology, virology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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