Lead discovery strategies for identification of Chlamydia pneumoniae inhibitors

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Hanski , L L & Vuorela , P 2016 , ' Lead discovery strategies for identification of Chlamydia pneumoniae inhibitors ' Microorganisms , vol. 4 , no. 4 , E43 . DOI: 10.3390/microorganisms4040043

Title: Lead discovery strategies for identification of Chlamydia pneumoniae inhibitors
Author: Hanski, Leena Lyydia; Vuorela, Pia
Contributor: University of Helsinki, Division of Pharmaceutical Biosciences
University of Helsinki, Faculty of Pharmacy
Date: 2016-11-28
Language: eng
Number of pages: 13
Belongs to series: Microorganisms
ISSN: 2076-2607
URI: http://hdl.handle.net/10138/230816
Abstract: Throughout its known history, the gram-negative bacterium Chlamydia pneumoniae has remained a challenging target for antibacterial chemotherapy and drug discovery. Owing to its well-known propensity for persistence and recent reports on antimicrobial resistence within closely related species, new approaches for targeting this ubiquitous human pathogen are urgently needed. In this review, we describe the strategies that have been successfully applied for the identification of nonconventional antichlamydial agents, including target-based and ligand-based virtual screening, ethnopharmacological approach and pharmacophore-based design of antimicrobial peptide-mimicking compounds. Among the antichlamydial agents identified via these strategies, most translational work has been carried out with plant phenolics. Thus, currently available data on their properties as antichlamydial agents are described, highlighting their potential mechanisms of action. In this context, the role of mitogen-activated protein kinase activation in the intracellular growth and survival of C. pneumoniae is discussed. Owing to the complex and often complementary pathways applied by C. pneumoniae in the different stages of its life cycle, multitargeted therapy approaches are expected to provide better tools for antichlamydial therapy than agents with a single molecular target.
Subject: 317 Pharmacy
Gram-negative bacterium, Chlamydia pneumoniae, drug discovery
Chlamydia pneumoni ae
antichlamydial agent
plant phenolics
antimicrobial peptide
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