Evidence for spared attention to faces in 7-month-old infants after prenatal exposure to antiepileptic drugs

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Videman , M , Stjerna , S , Roivainen , R , Nybo , T , Vanhatalo , S , Gaily , E & Leppanen , J M 2016 , ' Evidence for spared attention to faces in 7-month-old infants after prenatal exposure to antiepileptic drugs ' , Epilepsy & Behavior , vol. 64 , pp. 62-68 . https://doi.org/10.1016/j.yebeh.2016.09.023

Title: Evidence for spared attention to faces in 7-month-old infants after prenatal exposure to antiepileptic drugs
Author: Videman, Mari; Stjerna, Susanna; Roivainen, Reina; Nybo, Taina; Vanhatalo, Sampsa; Gaily, Eija; Leppanen, Jukka M.
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Neurosciences
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2016-11
Language: eng
Number of pages: 7
Belongs to series: Epilepsy & Behavior
ISSN: 1525-5050
URI: http://hdl.handle.net/10138/230921
Abstract: Introduction: Prenatal antiepileptic drug (AED) exposure is associated with an increased risk of cognitive impairment and autism spectrum disorders detected mainly at the age of two to six years. We examined whether the developitiental aberrations associated with prenatal AED exposure-could be-detected already in infancy and whether effects on visual attention can be observed at this early age. Material and methods: We compared a prospective cohort of infants with in utero exposure to AED (n = 56) with infants without drug exposures (n = 62). The assessments performed at the age of seven months included standardized neurodevelopmental scores (Griffiths Mental Developmental Scale and Hammersmith Infant Neurological Examination) as well as a novel eye-tracking-based test for visual attention and orienting to faces. Background information included prospective collection of AED exposure data, pregnancy outcome, neuropsychological evaluation of the mothers, and information on maternal epilepsy type. Results: Carbamazepine, oxcarbazepine, and valproate, but not lamotrigine or levetiracetam, were associated with impaired early language abilities at the age of seven months. The general speed of visuospatial orienting or attentional bias for faces measured by eye-tracker-based tests did not differ between AED-exposed and control infants. Discussion: Our findings support the idea that prenatal AED exposure may impair verbal abilities, and this effect may be detected already in infancy. In contrast, the early development of attention to faces was spared after in utero AED exposure. (C) 2016 Elsevier Inc. All rights reserved.
Subject: Eye-tracking
Epilepsy
Pregnancy
Cognition
AED
Infant
AUTISM SPECTRUM DISORDER
IN-UTERO EXPOSURE
NEUROLOGIC EXAMINATION
COGNITIVE OUTCOMES
DEVELOPING BRAIN
EYE-TRACKING
EPILEPSY
CHILDREN
PREGNANCY
WOMEN
3112 Neurosciences
3124 Neurology and psychiatry
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