High PROX1 expression in gastric cancer predicts better survival

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http://hdl.handle.net/10138/231142

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Laitinen , A , Bockelman , C , Hagstrom , J , Kokkola , A , Kallio , P & Haglund , C 2017 , ' High PROX1 expression in gastric cancer predicts better survival ' , PLoS One , vol. 12 , no. 8 , 0183868 . https://doi.org/10.1371/journal.pone.0183868

Title: High PROX1 expression in gastric cancer predicts better survival
Author: Laitinen, Alli; Bockelman, Camilla; Hagstrom, Jaana; Kokkola, Arto; Kallio, Pauliina; Haglund, Caj
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Clinicum
University of Helsinki, II kirurgian klinikka
University of Helsinki, Research Programs Unit
University of Helsinki, Clinicum
Date: 2017-08-30
Language: eng
Number of pages: 10
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/231142
Abstract: Background PROX1 is a transcription factor involved in the development of various organs. It has also an important function in colorectal cancer progression. The aim of this study was to investigate the prognostic role of PROX1 expression in gastric cancer. Methods We evaluated PROX1 expression in gastric cancer by immunohistochemistry of tumor-tissue microarrays including tumor specimens from 283 patients who underwent surgery at Helsinki University Hospital. We investigated the association of PROX1 expression with clinicopathologic variables and patient survival. Results Cytoplasmic PROX1 reactivity was high in 56 (20.5%) and low in 217 (79.5%) cases. Low PROX1 immunostaining associated with diffuse cancer type (p = 0.002). In subgroup analysis, PROX1 was a significant marker of better prognosis in patients aged under 66 (p = 0.007), in those with intestinal cancer (p = 0.025), among men (p = 0.019), and in tumors of less than 5 cm diameter (p = 0.030). Patients with high PROX1 expression had a cancer-specific 5-year survival of 65.6% (95% CI 52.7-78.5), compared to 37.1% (95% CI 30.2-44.0) for those with low expression (p = 0.004, log-rank test). This result remained significant in multivariable analysis (HR = 0.56; 95% CI 0.35-0.90; p = 0.017). Conclusion In gastric cancer, high cytoplasmic PROX1 expression is an independent marker of better prognosis.
Subject: TUMOR-SUPPRESSOR
ADENOCARCINOMA
MUTATIONS
CELLS
GENE
3122 Cancers
3126 Surgery, anesthesiology, intensive care, radiology
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