Promoting ossification of calvarial defects in craniosynostosis surgery by demineralized bone plate and bone dust in different age groups

Show simple item record

dc.contributor.author Savolainen, M.
dc.contributor.author Ritvanen, A.
dc.contributor.author Hukki, J.
dc.contributor.author Vuola, P.
dc.contributor.author Telkka, J.
dc.contributor.author Leikola, J.
dc.date.accessioned 2018-01-21T22:08:25Z
dc.date.available 2021-12-16T22:45:11Z
dc.date.issued 2017-01
dc.identifier.citation Savolainen , M , Ritvanen , A , Hukki , J , Vuola , P , Telkka , J & Leikola , J 2017 , ' Promoting ossification of calvarial defects in craniosynostosis surgery by demineralized bone plate and bone dust in different age groups ' , Journal of Plastic, Reconstructive & Aesthetic Surgery , vol. 70 , no. 1 , pp. 110-119 . https://doi.org/10.1016/j.bjps.2016.09.012
dc.identifier.other PURE: 78546889
dc.identifier.other PURE UUID: b88b8251-abb0-4ce7-9b33-eff803cbdbd5
dc.identifier.other WOS: 000390537800017
dc.identifier.other Scopus: 84992145799
dc.identifier.uri http://hdl.handle.net/10138/231343
dc.description.abstract Correction of calvarial defects after calvarial vault reconstruction (CVR) is challenging in craniosynostosis patients of advanced age and typically employs autologous bone. Demineralized bone matrix (DBM) is a potential alternative material for autologous bone, but its use has not been extended to correct calvarial defects. CVR patients operated at the Department of Plastic Surgery, Helsinki University Hospital, during 2008-2010 were retrospectively reviewed. Inclusion criteria of the study were CVR patients who received DBM plate, with or without bone dust, on calvarial defects and who had suitable uncovered defect on the contralateral side as control. This study included 17 craniosynostosis and one positional plagiocephaly patient, whose mean age was 6.9 years (range 0.9-19 years). The mean follow-up time was 5.6 years. The fusion degree of all defects was measured from 1 week to 1 year postoperatively using three-dimensional computed tomography (3D CT) images by the OsiriX (R) method. Medical records were reviewed for DBM-related complications. A total of 26 defects were covered with a DBM plate (mean area 11.1 cm(2)) and 26 control defects were identified (mean area 7.8 cm2). The mean fusion degree of the DBM defects was 74% and 54% for the controls (p <0.001). The mean fusion degree of nine DBM defects that lacked bone dust deposition was 66% and 55% for the nine controls (p <0.059). The difference between the DBM and control defects was statistically significant for patients older than 30 months (p <0.03). No DBM-related complication was observed. DBM plate is a safe and useful material to promote ossification in calvarial defects in CVR. Furthermore, DBM appears to be more effective in older patients (> 30 months) than in younger patients or when used with bone dust. (C) 2016 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Journal of Plastic, Reconstructive & Aesthetic Surgery
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Demineralized bone
dc.subject Craniosynostosis
dc.subject surgery
dc.subject Calvarial defect
dc.subject Calvarial
dc.subject reconstruction
dc.subject INTRACRANIAL VOLUME
dc.subject SITE MORBIDITY
dc.subject MATRIX
dc.subject RECONSTRUCTION
dc.subject REPAIR
dc.subject ANGIOGENESIS
dc.subject ANTERIOR
dc.subject OUTCOMES
dc.subject HARVEST
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.title Promoting ossification of calvarial defects in craniosynostosis surgery by demineralized bone plate and bone dust in different age groups en
dc.type Article
dc.contributor.organization Plastiikkakirurgian yksikkö
dc.contributor.organization Clinicum
dc.contributor.organization Department of Surgery
dc.contributor.organization HUS Musculoskeletal and Plastic Surgery
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.bjps.2016.09.012
dc.relation.issn 1748-6815
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S1748681516302650_main.pdf 988.4Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record