Genome-wide DNA methylation in saliva and body size of adolescent girls

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http://hdl.handle.net/10138/231425

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Rounge , T B , Page , C M , Lepistö , M , Ellonen , P , Andreassen , B K & Weiderpass , E 2016 , ' Genome-wide DNA methylation in saliva and body size of adolescent girls ' , Epigenomics , vol. 8 , no. 11 , pp. 1495-1505 . https://doi.org/10.2217/epi-2016-0045

Title: Genome-wide DNA methylation in saliva and body size of adolescent girls
Author: Rounge, Trine B.; Page, Christian M.; Lepistö, Maija; Ellonen, Pekka; Andreassen, Bettina K.; Weiderpass, Elisabete
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2016-11
Language: eng
Number of pages: 11
Belongs to series: Epigenomics
ISSN: 1750-1911
URI: http://hdl.handle.net/10138/231425
Abstract: Aim: We performed an epigenome-wide association study within the Finnish Health in Teens cohort to identify differential DNA methylation and its association with BMI in adolescents. Materials & methods: Differential DNA methylation analyses of 3.1 million CpG sites were performed in saliva samples from 50 lean and 50 heavy adolescent girls by genome-wide targeted bisulfite-sequencing. Results: We identified 100 CpG sites with p-values <0.000524, seven regions by 'bumphunting' and five CpG islands that differed significantly between the two groups. The ten CpG sites and regions most strongly associated with BMI substantially overlapped with obesity-and insulin-related genes, including MC2R, IGFBPL1, IP6K1 and IGF2BP1. Conclusion: Our findings suggest an association between the saliva methylome and BMI in adolescence.
Subject: adolescents
BMI
DNA methylation
epigenome-wide association study
girls
insulin
melanocortin
obesity
saliva
targeted bisulfite-sequencing
PROMOTER METHYLATION
GENE-EXPRESSION
WEIGHT-LOSS
MASS INDEX
OBESITY
ASSOCIATION
INSULIN
DIET
AGE
OVERWEIGHT
3111 Biomedicine
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