Genome-wide DNA methylation in saliva and body size of adolescent girls

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dc.contributor.author Rounge, Trine B.
dc.contributor.author Page, Christian M.
dc.contributor.author Lepistö, Maija
dc.contributor.author Ellonen, Pekka
dc.contributor.author Andreassen, Bettina K.
dc.contributor.author Weiderpass, Elisabete
dc.date.accessioned 2018-01-22T14:42:01Z
dc.date.available 2018-01-22T14:42:01Z
dc.date.issued 2016-11
dc.identifier.citation Rounge , T B , Page , C M , Lepistö , M , Ellonen , P , Andreassen , B K & Weiderpass , E 2016 , ' Genome-wide DNA methylation in saliva and body size of adolescent girls ' , Epigenomics , vol. 8 , no. 11 , pp. 1495-1505 . https://doi.org/10.2217/epi-2016-0045
dc.identifier.other PURE: 76930532
dc.identifier.other PURE UUID: 6101539b-147b-400e-b873-11c26d36c5a6
dc.identifier.other WOS: 000387776300006
dc.identifier.other Scopus: 84994607419
dc.identifier.other ORCID: /0000-0001-6072-0489/work/52863080
dc.identifier.other ORCID: /0000-0002-2595-1465/work/67133256
dc.identifier.uri http://hdl.handle.net/10138/231425
dc.description.abstract Aim: We performed an epigenome-wide association study within the Finnish Health in Teens cohort to identify differential DNA methylation and its association with BMI in adolescents. Materials & methods: Differential DNA methylation analyses of 3.1 million CpG sites were performed in saliva samples from 50 lean and 50 heavy adolescent girls by genome-wide targeted bisulfite-sequencing. Results: We identified 100 CpG sites with p-values <0.000524, seven regions by 'bumphunting' and five CpG islands that differed significantly between the two groups. The ten CpG sites and regions most strongly associated with BMI substantially overlapped with obesity-and insulin-related genes, including MC2R, IGFBPL1, IP6K1 and IGF2BP1. Conclusion: Our findings suggest an association between the saliva methylome and BMI in adolescence. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Epigenomics
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject adolescents
dc.subject BMI
dc.subject DNA methylation
dc.subject epigenome-wide association study
dc.subject girls
dc.subject insulin
dc.subject melanocortin
dc.subject obesity
dc.subject saliva
dc.subject targeted bisulfite-sequencing
dc.subject PROMOTER METHYLATION
dc.subject GENE-EXPRESSION
dc.subject WEIGHT-LOSS
dc.subject MASS INDEX
dc.subject OBESITY
dc.subject ASSOCIATION
dc.subject INSULIN
dc.subject DIET
dc.subject AGE
dc.subject OVERWEIGHT
dc.subject 3111 Biomedicine
dc.title Genome-wide DNA methylation in saliva and body size of adolescent girls en
dc.type Article
dc.contributor.organization Institute for Molecular Medicine Finland
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.2217/epi-2016-0045
dc.relation.issn 1750-1911
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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