Genome-wide DNA methylation in saliva and body size of adolescent girls

Show simple item record Rounge, Trine B. Page, Christian M. Lepistö, Maija Ellonen, Pekka Andreassen, Bettina K. Weiderpass, Elisabete 2018-01-22T14:42:01Z 2018-01-22T14:42:01Z 2016-11
dc.identifier.citation Rounge , T B , Page , C M , Lepistö , M , Ellonen , P , Andreassen , B K & Weiderpass , E 2016 , ' Genome-wide DNA methylation in saliva and body size of adolescent girls ' , Epigenomics , vol. 8 , no. 11 , pp. 1495-1505 .
dc.identifier.other PURE: 76930532
dc.identifier.other PURE UUID: 6101539b-147b-400e-b873-11c26d36c5a6
dc.identifier.other WOS: 000387776300006
dc.identifier.other Scopus: 84994607419
dc.identifier.other ORCID: /0000-0001-6072-0489/work/52863080
dc.identifier.other ORCID: /0000-0002-2595-1465/work/67133256
dc.description.abstract Aim: We performed an epigenome-wide association study within the Finnish Health in Teens cohort to identify differential DNA methylation and its association with BMI in adolescents. Materials & methods: Differential DNA methylation analyses of 3.1 million CpG sites were performed in saliva samples from 50 lean and 50 heavy adolescent girls by genome-wide targeted bisulfite-sequencing. Results: We identified 100 CpG sites with p-values <0.000524, seven regions by 'bumphunting' and five CpG islands that differed significantly between the two groups. The ten CpG sites and regions most strongly associated with BMI substantially overlapped with obesity-and insulin-related genes, including MC2R, IGFBPL1, IP6K1 and IGF2BP1. Conclusion: Our findings suggest an association between the saliva methylome and BMI in adolescence. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Epigenomics
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject adolescents
dc.subject BMI
dc.subject DNA methylation
dc.subject epigenome-wide association study
dc.subject girls
dc.subject insulin
dc.subject melanocortin
dc.subject obesity
dc.subject saliva
dc.subject targeted bisulfite-sequencing
dc.subject WEIGHT-LOSS
dc.subject MASS INDEX
dc.subject OBESITY
dc.subject ASSOCIATION
dc.subject INSULIN
dc.subject DIET
dc.subject AGE
dc.subject OVERWEIGHT
dc.subject 3111 Biomedicine
dc.title Genome-wide DNA methylation in saliva and body size of adolescent girls en
dc.type Article
dc.contributor.organization Institute for Molecular Medicine Finland
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1750-1911
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
epi_2016_0045.pdf 1.176Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record