Fatal Puumala Hantavirus Disease : Involvement of Complement Activation and Vascular Leakage in the Pathobiology

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http://hdl.handle.net/10138/231541

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Sironen , T , Sane , J , Lokki , M-L , Meri , S , Andersson , L C , Hautala , T , Kauma , H , Vuorinen , S , Rasmuson , J , Evander , M , Ahlm , C & Vaheri , A 2017 , ' Fatal Puumala Hantavirus Disease : Involvement of Complement Activation and Vascular Leakage in the Pathobiology ' , Open Forum Infectious Diseases , vol. 4 , no. 4 , 229 . https://doi.org/10.1093/ofid/ofx229

Title: Fatal Puumala Hantavirus Disease : Involvement of Complement Activation and Vascular Leakage in the Pathobiology
Author: Sironen, Tarja; Sane, Jussi; Lokki, Marja-Liisa; Meri, Seppo; Andersson, Leif C.; Hautala, Timo; Kauma, Heikki; Vuorinen, Sakari; Rasmuson, Johan; Evander, Magnus; Ahlm, Clas; Vaheri, Antti
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Umeå University
Date: 2017
Language: eng
Number of pages: 4
Belongs to series: Open Forum Infectious Diseases
ISSN: 2328-8957
URI: http://hdl.handle.net/10138/231541
Abstract: The case-fatality rate of hantavirus disease depends strongly on the causative hantavirus, ranging from 0.1% to 40%. However, the pathogenesis is not fully understood, and at present no licensed therapies exist. We describe fatal cases caused by Puumala hantavirus indicating involvement of complement activation and vascular leakage.
Subject: case-fatality rate
complement
hantavirus
Puumala virus
vascular leakage
NEPHROPATHIA-EPIDEMICA
HEMORRHAGIC-FEVER
VIRUS
PATHOGENESIS
INFECTION
3111 Biomedicine
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