Hair Cortisol in Twins : Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

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Rietschel , L , Streit , F , Zhu , G , McAloney , K , Frank , J , Couvy-Duchesne , B , Witt , S H , Binz , T M , McGrath , J , Hickie , I B , Hansell , N K , Wright , M J , Gillespie , N A , Forstner , A J , Schulze , T G , Wust , S , Nothen , M M , Baumgartner , M R , Walker , B R , Crawford , A A , Colodro-Conde , L , Medland , S E , Martin , N G , Rietschel , M , CORtisolNETwork CORNET Consortium , Major Depressive Disorder & Palotie , A 2017 , ' Hair Cortisol in Twins : Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes ' , Scientific Reports , vol. 7 , 15351 .

Title: Hair Cortisol in Twins : Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes
Author: Rietschel, Liz; Streit, Fabian; Zhu, Gu; McAloney, Kerrie; Frank, Josef; Couvy-Duchesne, Baptiste; Witt, Stephanie H.; Binz, Tina M.; McGrath, John; Hickie, Ian B.; Hansell, Narelle K.; Wright, Margaret J.; Gillespie, Nathan A.; Forstner, Andreas J.; Schulze, Thomas G.; Wust, Stefan; Nothen, Markus M.; Baumgartner, Markus R.; Walker, Brian R.; Crawford, Andrew A.; Colodro-Conde, Lucia; Medland, Sarah E.; Martin, Nicholas G.; Rietschel, Marcella; CORtisolNETwork CORNET Consortium; Major Depressive Disorder; Palotie, Aarno
Contributor organization: Centre of Excellence in Complex Disease Genetics
Research Programme of Molecular Medicine
Research Programs Unit
Aarno Palotie / Principal Investigator
Institute for Molecular Medicine Finland
Genomics of Neurological and Neuropsychiatric Disorders
Date: 2017-11-10
Language: eng
Number of pages: 15
Belongs to series: Scientific Reports
ISSN: 2045-2322
Abstract: Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables.
Description: A. Palotie on työryhmän jäsen.
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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