Candidate proteins from predegenerated nerve exert time-specific protection of retinal ganglion cells in glaucoma

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Pietrucha-Dutczak , M , Smedowski , A , Liu , X , Matuszek , I , Varjosalo , M & Lewin-Kowalik , J 2017 , ' Candidate proteins from predegenerated nerve exert time-specific protection of retinal ganglion cells in glaucoma ' , Scientific Reports , vol. 7 , 14540 . https://doi.org/10.1038/s41598-017-14860-5

Title: Candidate proteins from predegenerated nerve exert time-specific protection of retinal ganglion cells in glaucoma
Author: Pietrucha-Dutczak, Marita; Smedowski, Adrian; Liu, Xiaonan; Matuszek, Iwona; Varjosalo, Markku; Lewin-Kowalik, Joanna
Other contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute of Biotechnology

Date: 2017-11-06
Language: eng
Number of pages: 14
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-017-14860-5
URI: http://hdl.handle.net/10138/231832
Abstract: Glaucoma is thought to be the main cause of severe visual impairment or permanent loss of vision. Current therapeutic strategies are not sufficient to protect against glaucoma. Thus, new therapies and potential novel therapeutic targets must be developed to achieve progress in the treatment of this insidious disease. This study was undertaken to verify whether the time of administration of an extract from predegenerated rat sciatic nerves as well as exposure time of this extract onto retinal ganglion cells (RGCs) influences the survival of RGCs in a rat glaucoma model. We have demonstrated that extract obtained from the predegenerated sciatic nerves protects RGCs in a rat glaucoma model. The neuroprotective effect depends mostly on the time of administration of the extract and less clearly on the time of exposure to the extract and is associated with stimulation of endogenous BDNF expression both in RGCs and glial cells. The 14th day following glaucoma induction represents a therapeutic window for effective treatment in a glaucoma model. Mass Spectrometry analysis demonstrated that metallothionein 2 (MT2) may be a key molecule responsible for neuroprotective effects on RGC survival.
Subject: GLIA MATURATION FACTOR
OPEN-ANGLE GLAUCOMA
DEGENERATED PERIPHERAL-NERVES
ELEVATED INTRAOCULAR-PRESSURE
MESSENGER-RNA STABILITY
NORMAL-TENSION GLAUCOMA
NEURODEGENERATIVE DISEASES
OCULAR HYPERTENSION
ALZHEIMERS-DISEASE
SCIATIC-NERVES
1182 Biochemistry, cell and molecular biology
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