Manipulating Superparamagnetic Microparticles with an Electromagnetic Needle

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http://hdl.handle.net/10138/231869

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Cenev , Z , Zhang , H , Sariola , V , Rahikkala , A T A , Almeida Santos , H , Liu , D & Zhou , Q 2018 , ' Manipulating Superparamagnetic Microparticles with an Electromagnetic Needle ' , Advanced Materials Technologies , vol. 3 , no. 1 , 1700177 . https://doi.org/10.1002/admt.201700177

Title: Manipulating Superparamagnetic Microparticles with an Electromagnetic Needle
Author: Cenev, Zoran; Zhang, Hongbo; Sariola, Veikko; Rahikkala, Antti Tuomas Antero; Almeida Santos, Helder; Liu, Dongfei; Zhou, Quan
Contributor: University of Helsinki, Åbo Academy University
University of Helsinki, Preclinical Drug Formulation and Analysis group
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
Date: 2018-01-15
Language: eng
Number of pages: 9
Belongs to series: Advanced Materials Technologies
ISSN: 2365-709X
URI: http://hdl.handle.net/10138/231869
Abstract: Selective, precise, and high-throughput manipulation of individual superparamagnetic microparticles has profound applications in performing location-tailored in vitro biomedical studies. The current techniques for manipulation of microparticles allow only a single particle in the manipulation workspace, or simultaneous transportation of multiple microparticles in batches. In this work, a method based on a robotized electromagnetic needle for manipulation of individual superparamagnetic microparticles within a microparticle population is introduced. By automatically controlling the highly localized magnetic field of the needle, a single microparticle is selectively picked when its neighboring particle is few micrometers away. Supported by the nanometer resolution of the robotic positioner, particles are placed at sub-micrometer precision. This manipulation technique allows the creating of arbitrary patterns, sorting of microparticles based on size and morphology, and transporting of individual microparticles in 3D space. Therefore, this approach has the potential to enable more deterministic and quantitative microanalysis and microsynthesis using superparamagnetic microparticles.
Subject: 221 Nano-technology
216 Materials engineering
317 Pharmacy
electromagnetic needles
individual
manipulation
superparamagnetic microparticles
ON-CHIP MANIPULATION
MAGNETIC NANOPARTICLES
BIOLOGICAL-SYSTEMS
PARTICLES
FORCE
CELLS
TWEEZERS
BEADS
MICROSCOPY
PLATFORM
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