Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9 : Inflammation Imaging and Radiation Dosimetry

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Virtanen , H , Silvola , J M U , Autio , A , Li , X-G , Liljenback , H , Hellberg , S , Siitonen , R , Ståhle , M , Käkelä , M , Airaksinen , A J , Helariutta , K , Tolvanen , T , Veres , T Z , Saraste , A , Knuuti , J , Jalkanen , S & Roivainen , A 2017 , ' Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9 : Inflammation Imaging and Radiation Dosimetry ' , Contrast Media & Molecular Imaging , pp. 1-10 . https://doi.org/10.1155/2017/7645070

Title: Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9 : Inflammation Imaging and Radiation Dosimetry
Author: Virtanen, Helena; Silvola, Johanna M. U.; Autio, Anu; Li, Xiang-Guo; Liljenback, Heidi; Hellberg, Sanna; Siitonen, Riikka; Ståhle, Mia; Käkelä, Meeri; Airaksinen, Anu J.; Helariutta, Kerttuli; Tolvanen, Tuula; Veres, Tibor Z.; Saraste, Antti; Knuuti, Juhani; Jalkanen, Sirpa; Roivainen, Anne
Contributor organization: Department of Chemistry
Tracers in Molecular Imaging (TRIM)
Date: 2017
Language: eng
Number of pages: 10
Belongs to series: Contrast Media & Molecular Imaging
ISSN: 1555-4309
DOI: https://doi.org/10.1155/2017/7645070
URI: http://hdl.handle.net/10138/231873
Abstract: Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP1). We compared Ga-68-DOTA-and F-18-fluorodeoxyribose-(FDR) labeled Siglec-9motif peptides for PET imaging of inflammation. Methods. Firstly, we examined Ga-68-DOTA-Siglec-9 and F-18-FDR-Siglec-9 in rats with skin/muscle inflammation. We then studied F-18-FDR-Siglec-9 for the detection of inflamed atherosclerotic plaques in mice and compared it with previous Ga-68-DOTA-Siglec-9 results. Lastly, we estimated human radiation dosimetry fromthe rat data. Results. In rats, Ga-68-DOTA-Siglec-9 (SUV, 0.88 +/- 0.087) and F-18-FDR-Siglec-9 (SUV, 0.77 +/- 0.22) showed comparable (P = 0.29) imaging of inflammation. In atherosclerotic mice, 18 FFDR- Siglec-9 detected inflamed plaques with a target-to-background ratio (1.6 1/8 0.078) similar to previously tested Ga-68-DOTASiglec- 9 (P = 0.35). Humaneffectivedose estimates for Ga-68-DOTA-Siglec-9 and (18) F-FDR-Siglec-9were 0.024 and 0.022 mSv/MBq, respectively. Conclusion. Both tracers are suitable for PET imaging of inflammation. The easier production and lower cost of (68)GaDOTA-Siglec-9 present advantages over F-18-FDR-Siglec-9, indicating it as a primary choice for clinical studies.
Subject: VASCULAR ADHESION PROTEIN-1
ATHEROSCLEROTIC PLAQUES
SIGLEC-9
PEPTIDE
MOUSE
116 Chemical sciences
317 Pharmacy
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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