Intracerebral hemorrhage location and outcome among INTERACT2 participants

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INTERACT2 Investigators , Kaste , M & Tatlisumak , T 2017 , ' Intracerebral hemorrhage location and outcome among INTERACT2 participants ' , Neurology , vol. 88 , no. 15 , pp. 1408-1414 . https://doi.org/10.1212/WNL.0000000000003771

Title: Intracerebral hemorrhage location and outcome among INTERACT2 participants
Author: INTERACT2 Investigators; Kaste, Markku; Tatlisumak, Turgut
Other contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Neurosciences



Date: 2017-04-11
Language: eng
Number of pages: 7
Belongs to series: Neurology
ISSN: 0028-3878
DOI: https://doi.org/10.1212/WNL.0000000000003771
URI: http://hdl.handle.net/10138/231878
Abstract: Objective: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. Results: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score ( Conclusion: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule.
Subject: QUALITY-OF-LIFE
INTERNAL CAPSULE
CLINICAL-FEATURES
STROKE
POPULATION
PREDICTION
MORTALITY
OLDER
SCORE
PAIN
3112 Neurosciences
3124 Neurology and psychiatry
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