Body mass index and breast cancer survival : a Mendelian randomization analysis

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Guo , Q , Burgess , S , Turman , C , Bolla , M K , Wang , Q , Lush , M , Abraham , J , Aittomäki , K , Andrulis , I L , Apicella , C , Arndt , V , Barrdahl , M , Benitez , J , Berg , C D , Blomqvist , C , Bojesen , S E , Bonanni , B , Brand , J S , Brenner , H , Broeks , A , Burwinkel , B , Caldas , C , Campa , D , Canzian , F , Chang-Claude , J , Chanock , S J , Chin , S-F , Couch , F J , Cox , A , Cross , S S , Cybulski , C , Czene , K , Darabi , H , Devilee , P , Diver , W R , Dunning , A M , Earl , H M , Eccles , D M , Ekici , A B , Eriksson , M , Evans , D G , Fasching , P A , Figueroa , J , Flesch-Janys , D , Flyger , H , Gapstur , S M , Gaudet , M M , Giles , G G , Muranen , T A , Nevanlinna , H & kConFab-AOCS Investigators 2017 , ' Body mass index and breast cancer survival : a Mendelian randomization analysis ' , International Journal of Epidemiology , vol. 46 , no. 6 , pp. 1814-1822 . https://doi.org/10.1093/ije/dyx131

Title: Body mass index and breast cancer survival : a Mendelian randomization analysis
Author: Guo, Qi; Burgess, Stephen; Turman, Constance; Bolla, Manjeet K.; Wang, Qin; Lush, Michael; Abraham, Jean; Aittomäki, Kristiina; Andrulis, Irene L.; Apicella, Carmel; Arndt, Volker; Barrdahl, Myrto; Benitez, Javier; Berg, Christine D.; Blomqvist, Carl; Bojesen, Stig E.; Bonanni, Bernardo; Brand, Judith S.; Brenner, Hermann; Broeks, Annegien; Burwinkel, Barbara; Caldas, Carlos; Campa, Daniele; Canzian, Federico; Chang-Claude, Jenny; Chanock, Stephen J.; Chin, Suet-Feung; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Cybulski, Cezary; Czene, Kamila; Darabi, Hatef; Devilee, Peter; Diver, W. Ryan; Dunning, Alison M.; Earl, Helena M.; Eccles, Diana M.; Ekici, Arif B.; Eriksson, Mikael; Evans, D. Gareth; Fasching, Peter A.; Figueroa, Jonine; Flesch-Janys, Dieter; Flyger, Henrik; Gapstur, Susan M.; Gaudet, Mia M.; Giles, Graham G.; Muranen, Taru A.; Nevanlinna, Heli; kConFab-AOCS Investigators
Contributor organization: Medicum
Kristiina Aittomäki / Principal Investigator
Department of Medical and Clinical Genetics
University of Helsinki
Clinicum
Department of Oncology
Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
HUS Comprehensive Cancer Center
Date: 2017-12
Language: eng
Number of pages: 9
Belongs to series: International Journal of Epidemiology
ISSN: 0300-5771
DOI: https://doi.org/10.1093/ije/dyx131
URI: http://hdl.handle.net/10138/231972
Abstract: There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer. We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were pooled using fixed-effect meta-analysis. BMI genetic score was found to be associated with reduced breast cancer-specific survival for estrogen receptor (ER)-positive cases [hazard ratio (HR) = 1.11, per one-unit increment of GRS, 95% confidence interval (CI) 1.01-1.22, P = 0.03). We observed no association for ER-negative cases (HR = 1.00, per one-unit increment of GRS, 95% CI 0.89-1.13,P = 0.95). Our findings suggest a causal effect of increased BMI on reduced breast cancer survival for ER-positive breast cancer. There is no evidence of a causal effect of higher BMI on survival for ER-negative breast cancer cases.
Subject: Body mass index
breast cancer survival
Mendelian randomization
epidemiology
genetics
OBESITY
WOMEN
DIAGNOSIS
DISEASE
EPIDEMIOLOGY
METAANALYSIS
INSTRUMENTS
REGRESSION
PROGNOSIS
TRIAL
3142 Public health care science, environmental and occupational health
3122 Cancers
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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