Body mass index and breast cancer survival : a Mendelian randomization analysis

Show full item record



Permalink

http://hdl.handle.net/10138/231972

Citation

Guo , Q , Burgess , S , Turman , C , Bolla , M K , Wang , Q , Lush , M , Abraham , J , Aittomäki , K , Andrulis , I L , Apicella , C , Arndt , V , Barrdahl , M , Benitez , J , Berg , C D , Blomqvist , C , Bojesen , S E , Bonanni , B , Brand , J S , Brenner , H , Broeks , A , Burwinkel , B , Caldas , C , Campa , D , Canzian , F , Chang-Claude , J , Chanock , S J , Chin , S-F , Couch , F J , Cox , A , Cross , S S , Cybulski , C , Czene , K , Darabi , H , Devilee , P , Diver , W R , Dunning , A M , Earl , H M , Eccles , D M , Ekici , A B , Eriksson , M , Evans , D G , Fasching , P A , Figueroa , J , Flesch-Janys , D , Flyger , H , Gapstur , S M , Gaudet , M M , Giles , G G , Muranen , T A , Nevanlinna , H & kConFab AOCS Investigators 2017 , ' Body mass index and breast cancer survival : a Mendelian randomization analysis ' , International Journal of Epidemiology , vol. 46 , no. 6 , pp. 1814-1822 . https://doi.org/10.1093/ije/dyx131

Title: Body mass index and breast cancer survival : a Mendelian randomization analysis
Author: Guo, Qi; Burgess, Stephen; Turman, Constance; Bolla, Manjeet K.; Wang, Qin; Lush, Michael; Abraham, Jean; Aittomäki, Kristiina; Andrulis, Irene L.; Apicella, Carmel; Arndt, Volker; Barrdahl, Myrto; Benitez, Javier; Berg, Christine D.; Blomqvist, Carl; Bojesen, Stig E.; Bonanni, Bernardo; Brand, Judith S.; Brenner, Hermann; Broeks, Annegien; Burwinkel, Barbara; Caldas, Carlos; Campa, Daniele; Canzian, Federico; Chang-Claude, Jenny; Chanock, Stephen J.; Chin, Suet-Feung; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Cybulski, Cezary; Czene, Kamila; Darabi, Hatef; Devilee, Peter; Diver, W. Ryan; Dunning, Alison M.; Earl, Helena M.; Eccles, Diana M.; Ekici, Arif B.; Eriksson, Mikael; Evans, D. Gareth; Fasching, Peter A.; Figueroa, Jonine; Flesch-Janys, Dieter; Flyger, Henrik; Gapstur, Susan M.; Gaudet, Mia M.; Giles, Graham G.; Muranen, Taru A.; Nevanlinna, Heli; kConFab AOCS Investigators
Contributor: University of Helsinki, Medicum
University of Helsinki, Clinicum
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Department of Obstetrics and Gynecology
Date: 2017-12
Language: eng
Number of pages: 9
Belongs to series: International Journal of Epidemiology
ISSN: 0300-5771
URI: http://hdl.handle.net/10138/231972
Abstract: There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer. We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were pooled using fixed-effect meta-analysis. BMI genetic score was found to be associated with reduced breast cancer-specific survival for estrogen receptor (ER)-positive cases [hazard ratio (HR) = 1.11, per one-unit increment of GRS, 95% confidence interval (CI) 1.01-1.22, P = 0.03). We observed no association for ER-negative cases (HR = 1.00, per one-unit increment of GRS, 95% CI 0.89-1.13,P = 0.95). Our findings suggest a causal effect of increased BMI on reduced breast cancer survival for ER-positive breast cancer. There is no evidence of a causal effect of higher BMI on survival for ER-negative breast cancer cases.
Subject: Body mass index
breast cancer survival
Mendelian randomization
epidemiology
genetics
OBESITY
WOMEN
DIAGNOSIS
DISEASE
EPIDEMIOLOGY
METAANALYSIS
INSTRUMENTS
REGRESSION
PROGNOSIS
TRIAL
3142 Public health care science, environmental and occupational health
3122 Cancers
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
dyx131.pdf 313.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record