Body mass index and breast cancer survival : a Mendelian randomization analysis

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Guo , Q , Burgess , S , Turman , C , Bolla , M K , Wang , Q , Lush , M , Abraham , J , Aittomäki , K , Andrulis , I L , Apicella , C , Arndt , V , Barrdahl , M , Benitez , J , Berg , C D , Blomqvist , C , Bojesen , S E , Bonanni , B , Brand , J S , Brenner , H , Broeks , A , Burwinkel , B , Caldas , C , Campa , D , Canzian , F , Chang-Claude , J , Chanock , S J , Chin , S-F , Couch , F J , Cox , A , Cross , S S , Cybulski , C , Czene , K , Darabi , H , Devilee , P , Diver , W R , Dunning , A M , Earl , H M , Eccles , D M , Ekici , A B , Eriksson , M , Evans , D G , Fasching , P A , Figueroa , J , Flesch-Janys , D , Flyger , H , Gapstur , S M , Gaudet , M M , Giles , G G , Muranen , T A , Nevanlinna , H & kConFab-AOCS Investigators 2017 , ' Body mass index and breast cancer survival : a Mendelian randomization analysis ' , International Journal of Epidemiology , vol. 46 , no. 6 , pp. 1814-1822 .

Title: Body mass index and breast cancer survival : a Mendelian randomization analysis
Author: Guo, Qi; Burgess, Stephen; Turman, Constance; Bolla, Manjeet K.; Wang, Qin; Lush, Michael; Abraham, Jean; Aittomäki, Kristiina; Andrulis, Irene L.; Apicella, Carmel; Arndt, Volker; Barrdahl, Myrto; Benitez, Javier; Berg, Christine D.; Blomqvist, Carl; Bojesen, Stig E.; Bonanni, Bernardo; Brand, Judith S.; Brenner, Hermann; Broeks, Annegien; Burwinkel, Barbara; Caldas, Carlos; Campa, Daniele; Canzian, Federico; Chang-Claude, Jenny; Chanock, Stephen J.; Chin, Suet-Feung; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Cybulski, Cezary; Czene, Kamila; Darabi, Hatef; Devilee, Peter; Diver, W. Ryan; Dunning, Alison M.; Earl, Helena M.; Eccles, Diana M.; Ekici, Arif B.; Eriksson, Mikael; Evans, D. Gareth; Fasching, Peter A.; Figueroa, Jonine; Flesch-Janys, Dieter; Flyger, Henrik; Gapstur, Susan M.; Gaudet, Mia M.; Giles, Graham G.; Muranen, Taru A.; Nevanlinna, Heli; kConFab-AOCS Investigators
Contributor organization: Medicum
Kristiina Aittomäki / Principal Investigator
Department of Medical and Clinical Genetics
University of Helsinki
Department of Oncology
Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
HUS Comprehensive Cancer Center
Date: 2017-12
Language: eng
Number of pages: 9
Belongs to series: International Journal of Epidemiology
ISSN: 0300-5771
Abstract: There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer. We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were pooled using fixed-effect meta-analysis. BMI genetic score was found to be associated with reduced breast cancer-specific survival for estrogen receptor (ER)-positive cases [hazard ratio (HR) = 1.11, per one-unit increment of GRS, 95% confidence interval (CI) 1.01-1.22, P = 0.03). We observed no association for ER-negative cases (HR = 1.00, per one-unit increment of GRS, 95% CI 0.89-1.13,P = 0.95). Our findings suggest a causal effect of increased BMI on reduced breast cancer survival for ER-positive breast cancer. There is no evidence of a causal effect of higher BMI on survival for ER-negative breast cancer cases.
Subject: Body mass index
breast cancer survival
Mendelian randomization
3142 Public health care science, environmental and occupational health
3122 Cancers
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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