Salivary MMP-13 Gender Differences in Periodontitis: A Cross-sectional Study from Sweden

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Virtanen , E , Yakob , M , Tervahartiala , T , Söder , P-Ö , Andersson , L C , Sorsa , T A , Meurman , J H & Söder , B 2017 , ' Salivary MMP-13 Gender Differences in Periodontitis: A Cross-sectional Study from Sweden ' , Clinical and Experimental Dental Research , vol. 3 , no. 5 , pp. 165-170 . https://doi.org/10.1002/cre2.76

Title: Salivary MMP-13 Gender Differences in Periodontitis: A Cross-sectional Study from Sweden
Author: Virtanen, Eunice; Yakob, Maha; Tervahartiala, Taina; Söder, Per-Östen; Andersson, Leif C.; Sorsa, Timo Arto; Meurman, Jukka H.; Söder, Birgitta
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Medicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2017-09-15
Language: eng
Number of pages: 6
Belongs to series: Clinical and Experimental Dental Research
ISSN: 2057-4347
URI: http://hdl.handle.net/10138/232180
Abstract: We investigated serum and saliva concentrations of matrix metalloproteinases, MMP-8, MMP-9 and MMP-13, and their tissue inhibitor TIMP-1, in a group of patients with and without periodontitis from Sweden. The hypothesis was that these biomarkers are higher in the periodontitis patients. 90 patients participated in this cross-sectional study. 51 patients had periodontitis while 39 were periodontally healthy. Saliva and serum samples were analyzed with immunofluorometric, enzyme-linked immunosorbent assay and western blot. Results were statistically analyzed with independent t-test, Mann-Whitney U-test, Bonferroni corrections and regression analyses. MMP-13 was not detected in serum but in saliva higher values were found among the periodontally healthy compared with periodontitis subjects (0.32±0.26 vs. 0.21±0.23 ng/ml, p<0.05). Female gender and clinical attachment loss (CAL) were the explanatory factors for higher salivary MMP-13 values with odds ratio (OR) 3.08 (95% confidence interval [CI] 1.17-8.11) and 3.57 (1.08-11.82), respectively. No statistically significant differences between groups was found in serum and saliva values of MMP-8, MMP-9 and TIMP-1, respectively. Contrary to our hypothesis, no statistically significant differences between patients with and without periodontitis was seen in MMP-8, MMP-9, and TIMP-1 values. However higher MMP-13 concentrations in saliva were associated with female gender and higher CAL. Metabolism of MMP-13 may thus have some gender implications in periodontitis.
Subject: 313 Dentistry
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