Anemia and low-grade inflammation in pediatric kidney transplant recipients

Näytä kaikki kuvailutiedot

Permalink

http://hdl.handle.net/10138/232263

Lähdeviite

Miettinen , J , Tainio , J , Jahnukainen , T , Pakarinen , M , Lauronen , J & Jalanko , H 2017 , ' Anemia and low-grade inflammation in pediatric kidney transplant recipients ' Pediatric Nephrology , vol 32 , no. 2 , pp. 347-358 . DOI: 10.1007/s00467-016-3481-7

Julkaisun nimi: Anemia and low-grade inflammation in pediatric kidney transplant recipients
Tekijä: Miettinen, Jenni; Tainio, Juuso; Jahnukainen, Timo; Pakarinen, Mikko; Lauronen, Jouni; Jalanko, Hannu
Muu tekijä: University of Helsinki, Clinicum
University of Helsinki, Children's Hospital
University of Helsinki, Children's Hospital
University of Helsinki, Children's Hospital
University of Helsinki, Children's Hospital
Kuuluu julkaisusarjaan: Pediatric Nephrology
ISSN: 0931-041X
Tiivistelmä: Anemia and low-grade inflammation are reported to be associated with impaired long-term graft outcome in renal transplant (RTx) recipients. In this study, hemoglobin (Hb) and inflammation marker levels were correlated with measured glomerular filtration rate (GFR) in 128 pediatric RTx recipients over a median follow-up period of 10 years. Serum levels of erythropoietin (EPO), hepcidin-25, high-sensitivity C-reactive protein (CRP) (hsCRP) and interleukin-6 (IL-6) were analyzed by enzyme-linked immunosorbent assays, and GFR was analyzed by Cr-51-EDTA clearance. The median levels of Hb (115 g/L), hsCRP (0.4 mg/L) and IL-6 (1.4 pg/mL) and the median erythrocyte sedimentation rate (ESR; 19 mm/h) remained stable after the first post-operative year. However, approximately half of the patients had a normocytic, normochromic anemia, and one-third had elevated levels of hsCRP (> 1 mg/L) and ESR (> 25 mm/h), indicating continuous low-grade inflammation. Low Hb levels preceded increased fibrosis in protocol biopsies taken at 1.5 and 3 years after transplantation and preceded decreased GFR by several years. Hb levels showed an inverse correlation with EPO levels (r = -0.206, p = 0.038) and ESR (r = -0.369, p <0.001), but not with hepcidin-25, hsCRP or IL-6 levels. The levels of the major inflammatory markers IL-6 and hsCRP did not show a significant correlation with GFR at either the early maintenance phase or later. In the multivariable analysis, low Hb levels performed better than any other marker with respect to predicting concomitant and subsequent GFR. Anemia, but not elevated inflammatory indices, was associated with poor concomitant and subsequent graft function during a 10-year follow-up in pediatric RTx patients.
URI: http://hdl.handle.net/10138/232263
Päiväys: 2017-02
Avainsanat: Anemia
Inflammation
Children
Glomerular filtration rate
Renal transplantation
SERUM ERYTHROPOIETIN LEVELS
RENAL-ALLOGRAFT RECIPIENTS
POSTTRANSPLANTATION ANEMIA
GRAFT FUNCTION
RISK-FACTORS
PREVALENCE
DISEASE
CHILDREN
SURVIVAL
PATIENT
3123 Gynaecology and paediatrics
3126 Surgery, anesthesiology, intensive care, radiology
Tekijänoikeustiedot:


Tiedostot

Latausmäärä yhteensä: Ladataan...

Tiedosto(t) Koko Formaatti Näytä
Anemia_and_low_grade_inflammation.pdf 921.6KB PDF Avaa tiedosto

Viite kuuluu kokoelmiin:

Näytä kaikki kuvailutiedot