Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia

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http://hdl.handle.net/10138/232438

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Paetau , S , Rolova , T , Ning , L & Gahmberg , C G 2017 , ' Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia ' , Frontiers in Molecular Neuroscience , vol. 10 , 431 . https://doi.org/10.3389/fnmol.2017.00431

Title: Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia
Author: Paetau, Sonja; Rolova, Taisia; Ning, Lin; Gahmberg, Carl G.
Contributor: University of Helsinki, Biosciences
University of Helsinki, Biosciences
University of Helsinki, Biosciences
University of Helsinki, Biosciences
Date: 2017-12-22
Language: eng
Number of pages: 12
Belongs to series: Frontiers in Molecular Neuroscience
ISSN: 1662-5099
URI: http://hdl.handle.net/10138/232438
Abstract: The intercellular adhesion molecule-5 (ICAM-5) regulates neurite outgrowth and synaptic maturation. ICAM-5 overexpression in the hippocampal neurons induces filopodia formation in vitro. Since microglia are known to prune supernumerous synapses during development, we characterized the regulatory effect of ICAM-5 on microglia. ICAM-5 was released as a soluble protein from N-methyl-D-aspartic acid (NMDA)-treated neurons and bound by microglia. ICAM-5 promoted down-regulation of adhesion and phagocytosis in vitro. Microglia formed large cell clusters on ICAM-5-coated surfaces whereas they adhered and spread on the related molecule ICAM-1. ICAM-5 further reduced the secretion of the proinflammatory cytokines tumor necrosis factor a (TNF-alpha) and interleukin 1 beta (IL-1 beta), but on the contrary induced the secretion of the antiinflammatory IL-10 from lipopolysaccharide (LPS) stimulated microglia. Thus, ICAM-5 might be involved in the regulation of microglia in both health and disease, playing an important neuroprotective role when the brain is under immune challenges and as a "don't-eat-me" signal when it is solubilized from active synapses.
Subject: ICAM-5
microglia
adhesion
phagocytosis
TNF-alpha
ICAM-1
integrin
SPINE MATURATION
LEUKOCYTE INTEGRIN
ALPHA-ACTININ
TELENCEPHALIN
MOLECULE
BINDING
GLYCOPROTEIN
ACTIVATION
CD11A/CD18
OUTGROWTH
1182 Biochemistry, cell and molecular biology
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