Bronchoalveolar lavage in infants with recurrent lower respiratory symptoms

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http://hdl.handle.net/10138/232489

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Malmström , K , Lehto , M , Majuri , M-L , Paavonen , T , Sarna , S , Pelkonen , A S , Malmberg , L P , Lindahl , H , Kajosaari , M , Saglani , S , Alenius , H & Makela , M J 2014 , ' Bronchoalveolar lavage in infants with recurrent lower respiratory symptoms ' , Clinical and Translational Allergy , vol. 4 , 35 . https://doi.org/10.1186/2045-7022-4-35

Title: Bronchoalveolar lavage in infants with recurrent lower respiratory symptoms
Author: Malmström, Kristiina; Lehto, Maili; Majuri, Marja-Leena; Paavonen, Timo; Sarna, Seppo; Pelkonen, Anna S.; Malmberg, L. Pekka; Lindahl, Harry; Kajosaari, Merja; Saglani, Sejal; Alenius, Harri; Makela, Mika J.
Contributor organization: Department of Dermatology, Allergology and Venereology
Clinicum
Seppo Sarna / Principal Investigator
Department of Public Health
Children's Hospital
Date: 2014
Language: eng
Number of pages: 7
Belongs to series: Clinical and Translational Allergy
ISSN: 2045-7022
DOI: https://doi.org/10.1186/2045-7022-4-35
URI: http://hdl.handle.net/10138/232489
Abstract: Background: Few data are available about the inflammatory cytokine profile of bronchoalveolar lavage (BAL) from young children with frequent wheeze. The first aim was to investigate the BAL cellular and cytokine profiles in infants with recurrent lower respiratory symptoms in whom bronchoscopy was indicated for clinical symptom evaluation. The second aim was to relate the BAL results with the histological findings of the endobronchial carina biopsies. Methods: Thirty-nine infants (median age 0.9 years) underwent lung function testing by whole-body plethysmography prior to the bronchoscopy. The BAL differential cell counts and cytokine levels were quantified. These findings were compared with the histological findings of the endobronchial carina biopsies. Results: The differential cytology reflected mainly that described for healthy infants with lymphocyte counts at the upper range level. A positive association between BAL CD8+ lymphocytes and neutrophils and endobronchial reticular basement membrane was found. Detectable levels of pro-inflammatory cytokine proteins IL-1 beta, IL-17A, IL-18, IL-23, and IL-33 were found, whereas levels of Th2-type cytokine proteins were low. Frequent wheeze was the only clinical characteristic significantly related to detectable combined pro-inflammatory cytokine profile. Lung function did not correlate with any cytokine. Conclusions: A positive association between BAL CD8+ lymphocytes and neutrophils and endobronchial reticular basement thickness was found. Detectable production of pro-inflammatory cytokines associated positively with frequent wheeze.
Subject: Bronchoalveolar lavage
Infant
Pro-inflammatory cytokines
Pulmonary function
Wheeze
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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