Somatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History : Evidence from Monozygotic Twins

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Hautasaari , P , Savic , A M , Loberg , O , Niskanen , E , Kaprio , J , Kujala , U M & Tarkka , I M 2017 , ' Somatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History : Evidence from Monozygotic Twins ' , Brain Topography , vol. 30 , no. 1 , pp. 77-86 . https://doi.org/10.1007/s10548-016-0531-1

Titel: Somatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History : Evidence from Monozygotic Twins
Författare: Hautasaari, Pekka; Savic, Andrej M.; Loberg, Otto; Niskanen, Eini; Kaprio, Jaakko; Kujala, Urho M.; Tarkka, Ina M.
Upphovmannens organisation: Clinicum
Institute for Molecular Medicine Finland
Jaakko Kaprio / Principal Investigator
Department of Public Health
Genetic Epidemiology
Datum: 2017-01
Språk: eng
Sidantal: 10
Tillhör serie: Brain Topography
ISSN: 0896-0267
DOI: https://doi.org/10.1007/s10548-016-0531-1
Permanenta länken (URI): http://hdl.handle.net/10138/232550
Abstrakt: Associations between long-term physical activity and cortical function and brain structure are poorly known. Our aim was to assess whether brain functional and/or structural modulation associated with long-term physical activity is detectable using a discordant monozygotic male twin pair design. Nine monozygotic male twin pairs were carefully selected for an intrapair difference in their leisure-time physical activity of at least three years duration (mean age 34 +/- 1 years). We registered somatosensory mismatch response (SMMR) in EEG to electrical stimulation of fingers and whole brain MR images. We obtained exercise history and measured physical fitness and body composition. Equivalent electrical dipole sources of SMMR as well as gray matter (GM) voxel counts in regions of interest indicated by source analysis were evaluated. SMMR dipolar source strengths differed between active and inactive twins within twin pairs in postcentral gyrus, medial frontal gyrus and superior temporal gyrus and in anterior cingulate (AC) GM voxel counts differed similarly. Compared to active twins, their inactive twin brothers showed greater dipole strengths in short periods of the deviant-elicited SMMR and larger AC GM voxel counts. Stronger activation in early unattended cortical processing of the deviant sensory signals in inactive co-twins may imply less effective gating of somatosensory information in inactive twins compared to their active brothers. Present findings indicate that already in 30's long-term physical activity pattern is linked with specific brain indices, both in functional and structural domains.
Subject: Twin research
Brain electrophysiology
Somatosensory cortex
Mismatch negativity
Brain structure
Physical activity
MISMATCH NEGATIVITY MMN
TIME PHYSICAL-ACTIVITY
DISCRIMINATION
RESPONSES
HEALTH
EXCITABILITY
GENERATORS
POTENTIALS
MODULATION
FITNESS
3142 Public health care science, environmental and occupational health
Referentgranskad: Ja
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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